Autor según el artículo: Babio, Nancy; Ibarrola-Jurado, Nuria; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Waernberg, Julia; Salaverria, Itziar; Ortega-Calvo, Manuel; Estruch, Ramon; Serra-Majem, Lluis; Isabel Covas, Maria; Vicente Sorli, Jose; Salas-Salvado, Jordi
Departamento: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica / Díaz López, Andres / Fernández Ballart, Joan Domènech / IBARROLA JURADO, NURIA / Martín Lujan, Francisco Manuel / Salas Salvadó, Jorge
Palabras clave: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
Resumen: The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS.Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n?=?4,377) and a prospective assessment (n?=?1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components.Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend<0.001). This association was also observed for all WBC subtypes, except for basophils. Compared to participants in the lowest quartile, those in the top quartile of leukocyte, neutrophil and lymphocyte count had an increased risk of MetS incidence. Leukocyte and neutrophil count were found to be strongly associated with the MetS components hypertriglyceridemia and low HDL-cholesterol. Likewise, lymphocyte counts were found to be associated with the incidence of the MetS components low HDL-cholesterol and high fasting glucose. An increase in the total WBC during the follow-up was also associated with an increased risk of MetS.Total WBC counts, and some subtypes, were positively associated with MetS as well as hypertriglyceridemia, low HDL-cholesterol and high fasting glucose, all components of MetS.Controlled-Trials.comISRCTN35739639.
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Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Direcció de correo del autor: andres.diaz@urv.cat paco.martin@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0002-7500-5629 0000-0003-0359-3588 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058354
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Plos One. 8 (3): 467-
Referencia de l'ítem segons les normes APA: Babio, Nancy; Ibarrola-Jurado, Nuria; Bullo, Monica; Angel Martinez-Gonzalez, Miguel; Waernberg, Julia; Salaverria, Itziar; Ortega-Calvo, Manuel; Estr (2013). White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study. Plos One, 8(3), 467-. DOI: 10.1371/journal.pone.0058354
DOI del artículo: 10.1371/journal.pone.0058354
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2013
Tipo de publicación: Journal Publications
Repositori URV