Autor según el artículo: Storniolo C., Casillas R., Bulló M., Castañer O., Ros E., Sáez G., Toledo E., Estruch R., Ruiz-Gutiérrez V., Fitó M., Martínez-González M., Salas-Salvadó J., Mitjavila M., Moreno J.

Departamento: Bioquímica i Biotecnologia Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge

Palabras clave: Predimed study Oxidative stress Nitric oxide Hypertension Endothelin-1 oxidative stress nitric oxide hypertension endothelin-1

Resumen: Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control.Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured.Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP.The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women.

Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental

Áreas temáticas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14366207

Direcció de correo del autor: jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://link.springer.com/article/10.1007/s00394-015-1060-5

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: European Journal Of Nutrition. 56 (1): 89-97

Referencia de l'ítem segons les normes APA: Storniolo C., Casillas R., Bulló M., Castañer O., Ros E., Sáez G., Toledo E., Estruch R., Ruiz-Gutiérrez V., Fitó M., Martínez-González M., Salas-Salv (2017). A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women. European Journal Of Nutrition, 56(1), 89-97. DOI: 10.1007/s00394-015-1060-5

DOI del artículo: 10.1007/s00394-015-1060-5

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications