Autor según el artículo: Casas R., Sacanella E., Urpí-Sardá M., Corella D., Castañr O., Lamuela-Raventos R., Salas-Salvadó J., Martínez-Gon?alez M., Ros E., Estruch R.

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Salas Salvadó, Jorge / Urpi Sarda, Mireia

Palabras clave: Peripheral blood mononuclear cells Mediterranean diet Long-term Inflammation Cardiovascular disease Adhesion molecules mediterranean diet long-term inflammation cardiovascular disease adhesion molecules

Resumen: The Mediterranean diet (MedDiet) has demonstrated short-term anti-inflammatory effects, but little is known about its long-term immunomodulatory properties.Our goal was to assess the long-term effects of the MedDiet on inflammatory markers related to atherogenesis in adults at high risk of cardiovascular disease (CVD) compared with the effects of a low-fat diet (LFD).We randomly assigned 165 high-risk participants (one-half men; mean age: 66 y) without overt CVD to 1 of 3 diets: a MedDiet supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or an LFD. Follow-up data were collected at 3 and 5 y. Repeated-measures ANOVA, adjusted for potential confounding variables, was used to evaluate changes in diet adherence, CVD risk factors, and inflammatory variables.The 2 MedDiet groups achieved a high degree of adherence to the intervention, and the LFD group had reduced energy intake from fat by 13% by 5 y. Compared with baseline, at 3 and 5 y, both MedDiet groups had significant reductions of ?16% in plasma concentrations of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor ?, and monocyte chemoattractant protein 1 (P ? 0.04), whereas there were no significant changes in the LFD group. The reductions in CD49d and CD40 expressions in T lymphocytes and monocytes at 3 y were ?16% greater in both MedDiet groups than were the changes in the LFD group (P < 0.001) at 3 y. Compared with baseline, at 3 y, the MedDiet groups had increased HDL-cholesterol (?8%) and decreased blood pressure (>4%) and total cholesterol, LDL-cholesterol, and triglyceride (?8%) concentrations. At 5 y, concentrations of glucose (13%) and glycated hemoglobin (8%) had increased with the LFD.The MedDiet participants had lower cellular and plasma concentrations of inflammatory markers related to atherosclerosis at 3 and 5 y. This anti-inflammatory role of the MedDiet could explain in part the long-term cardioprotective effect of the MedDiet against CVD. This trial was registered at controlled-trials.com as ISRCTN35739639.© 2016 American Society for Nutrition.

Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental

Áreas temáticas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00223166

Direcció de correo del autor: mireia.urpi@urv.cat jordi.salas@urv.cat

Identificador del autor: 0000-0003-2700-7459

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://academic.oup.com/jn/article/146/9/1684/4584874

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Journal Of Nutrition. 146 (9): 1684-1693

Referencia de l'ítem segons les normes APA: Casas R., Sacanella E., Urpí-Sardá M., Corella D., Castañr O., Lamuela-Raventos R., Salas-Salvadó J., Martínez-Gon?alez M., Ros E., Estruch R. (2016). Long-term immunomodulatory effects of a mediterranean diet in adults at high risk of cardiovascular disease in the prevención con dieta mediterŕanea (predimed) randomized controlled trial. Journal Of Nutrition, 146(9), 1684-1693. DOI: 10.3945/jn.115.229476

DOI del artículo: 10.3945/jn.115.229476

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Tipo de publicación: Journal Publications