Autor según el artículo: Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., Martínez J.

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Salas Salvadó, Jorge

Palabras clave: Methylation Mediterranean Epigenetics Dna Diet Adherence mediterranean epigenetics dna diet adherence

Resumen: Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-? and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact.

Áreas temáticas: Physiology Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biochemistry & molecular biology Biochemistry

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 11387548

Direcció de correo del autor: jordi.salas@urv.cat

Identificador del autor: 0000-0003-2700-7459

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://link.springer.com/article/10.1007/s13105-017-0552-6

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Journal Of Physiology And Biochemistry. 73 (3): 1-11

Referencia de l'ítem segons les normes APA: Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., M (2016). Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. Journal Of Physiology And Biochemistry, 73(3), 1-11. DOI: 10.1007/s13105-017-0552-6

DOI del artículo: 10.1007/s13105-017-0552-6

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Tipo de publicación: Journal Publications