Articles producció científica> Bioquímica i Biotecnologia

Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells

  • Datos identificativos

    Identificador: imarina:2943204
    Autores:
    Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., Martínez J.
    Resumen:
    Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-? and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact.
  • Otros:

    Autor según el artículo: Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., Martínez J.
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Salas Salvadó, Jorge
    Palabras clave: Methylation Mediterranean Epigenetics Dna Diet Adherence mediterranean epigenetics dna diet adherence
    Resumen: Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-? and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact.
    Áreas temáticas: Physiology Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biochemistry & molecular biology Biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 11387548
    Direcció de correo del autor: jordi.salas@urv.cat
    Identificador del autor: 0000-0003-2700-7459
    Fecha de alta del registro: 2024-06-15
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s13105-017-0552-6
    Referencia al articulo segun fuente origial: Journal Of Physiology And Biochemistry. 73 (3): 1-11
    Referencia de l'ítem segons les normes APA: Arpón A., Riezu-Boj J., Milagro F., Marti A., Razquin C., Martínez-González M., Corella D., Estruch R., Casas R., Fitó M., Ros E., Salas-Salvadó J., M (2016). Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells. Journal Of Physiology And Biochemistry, 73(3), 1-11. DOI: 10.1007/s13105-017-0552-6
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1007/s13105-017-0552-6
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Biochemistry & Molecular Biology,Medicine (Miscellaneous),Physiology
    Methylation
    Mediterranean
    Epigenetics
    Dna
    Diet
    Adherence
    mediterranean
    epigenetics
    dna
    diet
    adherence
    Physiology
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Enfermagem
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biochemistry & molecular biology
    Biochemistry
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