Autor según el artículo: Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M., Shivappa N., Wärnberg J., Gómez-Gracia E., Tur J.A., Salas-Salvadó J., Zulet M.A., Martínez J.A.
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Palabras clave: Systemic inflammation Risk Obesity Nonalcoholic fatty liver Nafld Metabolic syndrome Liver Inflammation Hepatocellular-carcinoma Follow-up Diet Consumption Cardiovascular-disease Association Adults nafld liver inflammation diet
Resumen: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study.A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-? and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated.A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern.This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02615614
Direcció de correo del autor: jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Clinical Nutrition. 37 (5): 1736-1743
Referencia de l'ítem segons les normes APA: Cantero I., Abete I., Babio N., Arós F., Corella D., Estruch R., Fitó M., Hebert J.R., Martínez-González M.Á., Pintó X., Portillo M.P., Ruiz-Canela M. (2018). Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clinical Nutrition, 37(5), 1736-1743. DOI: 10.1016/j.clnu.2017.06.027
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications
Repositori URV