Autor según el artículo: Riera-Borrull M., García-Heredia A., Fernández-Arroyo S., Hernández-Aguilera A., Cabré N., Cuyàs E., Luciano-Mateo F., Camps J., Menendez J.A., Joven J.
Departamento: Medicina i Cirurgia
e-ISSN: 1422-0067
Autor/es de la URV: Camps Andreu, Jorge / FERNANDEZ ARROYO, SALVADOR / Joven Maried, Jorge
Palabras clave: Metabolomics Liver steatosis Inflammation Fatty liver-disease Energy state Caloric restriction Adipose tissue therapy target one-carbon metabolism mice metabolomics liver steatosis insulin-resistance inflammation energy state drugs cancer caloric restriction adipose tissue
Resumen: Prevention of the metabolic consequences of a chronic energy-dense/high-fat diet (HFD) represents a public health priority. Metformin is a strong candidate to be incorporated in alternative therapeutic approaches. We used a targeted metabolomic approach to assess changes related to the multi-faceted metabolic disturbances provoked by HFD. We evaluated the protective effects of metformin and explored how pro-inflammatory and metabolic changes respond when mice rendered obese, glucose-intolerant and hyperlipidemic were switched to diet reversal with or without metformin. Mice treated with metformin and diet-reversal showed a dramatically improved protection against HFD-induced hepatic steatosis, a beneficial effect that was accompanied by a lowering of liver-infiltrating pro-inflammatory macrophages and lower release of pro-inflammatory cytokines. Metformin combined with diet reversal promoted effective weight loss along with better glucose control, lowered levels of circulating cholesterol and triglycerides, and reduced adipose tissue content. Our findings underscored the ability of metformin to target the contribution of branched chain amino acids to adipose tissue metabolism while suppressing mitochondrial-dependent biosynthesis in hepatic tissue. The relationship between adipose tissue and liver might provide clinical potential for combining metformin and dietary modifications to protect against the metabolic damage occurring upon excessive dietary fat intake.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14220067
Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
Fecha de alta del registro: 2023-02-18
Volumen de revista: 18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/18/11/2263
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 18 (11): E2263-
Referencia de l'ítem segons les normes APA: Riera-Borrull M., García-Heredia A., Fernández-Arroyo S., Hernández-Aguilera A., Cabré N., Cuyàs E., Luciano-Mateo F., Camps J., Menendez J.A., Joven (2017). Metformin potentiates the benefits of dietary restraint: A metabolomic study. International Journal Of Molecular Sciences, 18(11), E2263-. DOI: 10.3390/ijms18112263
DOI del artículo: 10.3390/ijms18112263
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV