Autor según el artículo: Murphy M., Fernandez-Ballart J., Molloy A., Canals J.

Departamento: Psicologia Ciències Mèdiques Bàsiques

Autor/es de la URV: Canals Sans, Josefa / Fernández Ballart, Joan Domènech / Murphy, Michelle

Palabras clave: Pregnancy Preconception Homocysteine Cognitive development preconception homocysteine cognitive development

Resumen: Prenatal methyl donor deficiency leads to homocysteine accumulation in the brain and impaired neurodevelopment in rats. We investigated the effect of moderately elevated preconception fasting total plasma homocysteine (tHcy) on child neurodevelopment in a prospective study of 67 and 76 mother¿child pairs at 4 months and 6 years of age, respectively. Fasting blood samples at 2¿10 weeks preconception, from the cord (nonfasting) and the mother and child 6 years after birth, were collected. Psychomotor and mental development were assessed at 4 months using the Bayley Scale of Infant Development (BSID) and cognitive development at 6 years using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Highest tertile preconception tHcy (≥9.04 µmol/L) was categorized as moderately elevated and low-mid tertile tHcy as normal. Children, born to mothers with moderately elevated compared to normal preconception tHcy, scored lower [mean (95% CI)] in the BSID psychomotor [115 (105, 124) vs. 126 (121, 130), p = 0.03] and mental [101 (93, 109) vs. 113 (107, 119), p = 0.03] development tests. Multiple logistic regression analysis showed that moderately elevated compared to normal preconception tHcy was associated with greater probability, OR (95%CI), of scoring in the lowest tertile for BSID psychomotor development (≤120): 4.0 (1.1, 14.3) and lowest tertiles for WPPSI full (≤111), verbal (≤104) and performance (≤111), intellectual quotient: 6.0 (1.5, 23.7), 3.5 (1.1, 11.2) and 4.1 (1.1, 15.7), respectively. We conclude that moderately elevated preconception tHcy is inversely associated with psychomotor and cognitive development scores in infants and children.

Áreas temáticas: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17408695

Direcció de correo del autor: josefa.canals@urv.cat michelle.murphy@urv.cat

Identificador del autor: 0000-0002-6209-9558 0000-0002-6304-6204

Fecha de alta del registro: 2023-02-22

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.12289

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Maternal And Child Nutrition. 13 (2):

Referencia de l'ítem segons les normes APA: Murphy M., Fernandez-Ballart J., Molloy A., Canals J. (2017). Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth. Maternal And Child Nutrition, 13(2), -. DOI: 10.1111/mcn.12289

DOI del artículo: 10.1111/mcn.12289

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications