Autor según el artículo: Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J.

Departamento: Medicina i Cirurgia Infermeria

Autor/es de la URV: Martorell Bonet, Lourdes / Ortega Sanz, Laura / Vilella Cuadrada, Elisabet

Palabras clave: Stress Early psychosis Diet Brain-derived neurotrophic factor Bdnf val66met early psychosis diet brain-derived neurotrophic factor bdnf val66met bdnf val66met

Resumen: The brain-derived neurotrophic factor (BDNF) is a major participant in the regulation of food intake and may play a role in the regulation of the stress response. We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis.We studied 124 early psychotic disorder (PD) patients, 36 At-Risk Mental States (ARMS) and 62 healthy subjects (HS). Dietary patterns were examined by a dietician. Physical activity, life stress and perceived stress were assessed by validated questionnaires. BDNF Val66Met polymorphism (rs6265) was genotyped. A gene-environment interaction was tested with multiple linear regression analysis while adjusting for covariates.Perceived stress was not associated with calorie intake in HS. In ARMS subjects, Met-carriers who presented low-perceived stress were associated with increased caloric intake. Conversely, those who presented high-perceived stress were associated with reduced caloric intake. In PD, perceived stress was neither associated with increased calorie intake without an effect by BDNF genotype nor a gene-environment interaction. Perceived stress was associated with food craving in PD patients, independent of genotype, and in ARMS or HS who were Val homozygous.This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis.© 2016 John Wiley & Sons Australia, Ltd.

Áreas temáticas: Psychiatry and mental health Psychiatry Psychiatric mental health Medicina ii Medicina i General medicine Ciencias sociales Biological psychiatry

ISSN: 17517885

Direcció de correo del autor: lourdes.martorell@urv.cat elisabet.vilella@urv.cat laura.ortega@urv.cat

Identificador del autor: 0000-0003-4999-2197 0000-0002-1887-5919 0000-0003-2476-7700

Fecha de alta del registro: 2023-02-22

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1111/eip.12371

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Early Intervention In Psychiatry. 12 (5): 811-820

Referencia de l'ítem segons les normes APA: Gattere G, Stojanovic-Pérez A, Monseny R, Martorell L, Ortega L, Montalvo I, Solé M, Algora MJ, Cabezas Á, Reynolds RM, Vilella E, Labad J. (2018). Gene-environment interaction between the brain-derived neurotrophic factor Val66Met polymorphism, psychosocial stress and dietary intake in early psychosis.. Early Intervention In Psychiatry, 12(5), 811-820. DOI: 10.1111/eip.12371

DOI del artículo: 10.1111/eip.12371

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications