Autor según el artículo: Hernández-Alonso P; Giardina S; Cañueto D; Salas-Salvadó J; Cañellas N; Bulló M

Departamento: Bioquímica i Biotecnologia Eng. Electrònica, Elèctrica i Automàtica

Autor/es de la URV: Bulló Bonet, Mònica / Cañellas Alberich, Nicolau / Salas Salvadó, Jorge

Palabras clave: Nutritional intervention Metabolomics Lipidomics Glycemic index metabolomics lipidomics glycemic index

Resumen: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: To examine whether a low-glycemic index (LGI) diet improves a set of plasma metabolites related to different metabolic diseases, and comparison to a high-glycemic index (HGI) diet and a low-fat (LF) diet. Methods and results: A parallel, randomized trial with three intervention diets: an LGI diet, an HGI diet, and an LF diet. A total of 122 adult overweight and obese subjects were enrolled in the study for 6 months. Blood samples were collected at baseline and at the end of the intervention. The plasma metabolomic profile of 102 subjects was analyzed using three different approaches: GC/quadrupole-TOF, LC/quadrupole-TOF, and nuclear magnetic resonance. Both univariate and multivariate analysis were performed. Serine levels were significantly higher following the LGI diet compared to both the HGI and LF diets (q = 0.002), whereas leucine (q = 0.015) and valine (q = 0.024) were lower in the LGI diet compared to the LF diet. A set of two sphingomyelins, two lysophosphatidylcholines, and six phosphatidylcholines were significantly modulated after the LGI diet compared to the HGI and LF diets (q < 0.05). Significant correlations between changes in plasma amino acids and lipid species with changes in body weight, glucose, insulin, and some inflammatory markers are also reported. Conclusion: These results suggest that an LGI diet modulates certain circulating amino acids and lipid levels. These findings may explain the health benefits attributed to LGI diets in metabolic diseases such as type 2 diabetes.

Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16134125

Direcció de correo del autor: nicolau.canyellas@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-4856-8132 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700975

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 63 (1): e1700975-

Referencia de l'ítem segons les normes APA: Hernández-Alonso P; Giardina S; Cañueto D; Salas-Salvadó J; Cañellas N; Bulló M (2019). Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index Diet Intervention. Molecular Nutrition & Food Research, 63(1), e1700975-. DOI: 10.1002/mnfr.201700975

DOI del artículo: 10.1002/mnfr.201700975

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Tipo de publicación: Journal Publications