Autor según el artículo: Ramon-Krauel M, Pentinat T, Bloks VW, Cebrià J, Ribo S, Pérez-Wienese R, Vilà M, Palacios-Marin I, Fernández-Pérez A, Vallejo M, Téllez N, Rodríguez MÀ, Yanes O, Lerin C, Díaz R, Plosch T, Tietge UJF, Jimenez-Chillaron JC

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica

Autor/es de la URV: Yanes Torrado, Óscar

Palabras clave: Weight-gain O-acyltransferase 1 Nutritional epigenetics Neonatal overfeeding Mouse model Monoacylglycerol acyltransferase Mice Lipid-accumulation In-utero High-fat diet Glucose Expression Childhood obesity

Resumen: Postnatal overfeeding increases the risk of chronic diseases later in life, including obesity, insulin resistance, hepatic steatosis, and type 2 diabetes. Epigenetic mechanisms might underlie the long-lasting effects associated with early nutrition. Here we aimed to explore the molecular pathways involved in early development of insulin resistance and hepatic steatosis, and we examined the potential contribution of DNA methylation and histone modifications to long-term programming of metabolic disease. We used a well-characterized mouse model of neonatal overfeeding and early adiposity by litter size reduction. Neonatal overfeeding led to hepatic insulin resistance very early in life that persisted throughout adulthood despite normalizing food intake. Up-regulation of monoacylglycerol O-acyltransferase ( Mogat) 1 conceivably mediates hepatic steatosis and insulin resistance through increasing intracellular diacylglycerol content. Early and sustained deregulation of Mogat1 was associated with a combination of histone modifications that might favor Mogat1 expression. In sum, postnatal overfeeding causes extremely rapid derangements of hepatic insulin sensitivity that remain relatively stable until adulthood. Epigenetic mechanisms, particularly histone modifications, could contribute to such long-lasting effects. Our data suggest that targeting hepatic monoacylglycerol acyltransferase activity during early life might provide a novel strategy to improve hepatic insulin sensitivity and prevent late-onset insulin resistance and fatty liver disease.-Ramon-Krauel, M., Pentinat, T., Bloks, V. W., Cebrià, J., Ribo, S., Pérez-Wienese, R., Vilà, M., Palacios-Marin, I., Fernández-Pérez, A., Vallejo, M., Téllez, N., Rodríguez, M. À., Yanes, O., Lerin, C., Díaz, R., Plosch, T., Tietge, U. J. F., Jimenez-Chillaron, J. C. Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance.

Áreas temáticas: Saúde coletiva Química Psicología Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Genetics General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Cell biology Biotecnología Biotechnology Biology Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 08926638

Direcció de correo del autor: oscar.yanes@urv.cat

Identificador del autor: 0000-0003-3695-7157

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201700717RR

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Faseb Journal. 32 (11): fj201700717RR-fj201700717RR

Referencia de l'ítem segons les normes APA: Ramon-Krauel M, Pentinat T, Bloks VW, Cebrià J, Ribo S, Pérez-Wienese R, Vilà M, Palacios-Marin I, Fernández-Pérez A, Vallejo M, Téllez N, Rodríguez M (2018). Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance.. Faseb Journal, 32(11), fj201700717RR-fj201700717RR. DOI: 10.1096/fj.201700717RR

DOI del artículo: 10.1096/fj.201700717rr

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications