Autor según el artículo: Pedret, Anna; Fernandez-Castillejo, Sara; Valls, Rosa-Maria; Catalan, Ursula; Rubio, Laura; Romeu, Marta; Macia, Alba; Lopez de las Hazas, Maria Carmen; Farras, Marta; Giralt, Montse; Mosele, Juana I; Martin-Pelaez, Sandra; Remaley, Alan T; Covas, Maria-Isabel; Fito, Montse; Motilva, Maria-Jose; Sola, Rosa
Departamento: Ciències Mèdiques Bàsiques; Medicina i Cirurgia
Autor/es de la URV: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Giralt Batista, Montserrat / Pedret Figuerola, Anna / Romeu Ferran, Marta / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Palabras clave: Virgin olive oil; Polyphenols; Phenolic compounds; Hdl functionality; Cardiovascular; polyphenols; phenolic compounds; hdl functionality; cardiovascular
Resumen: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol-enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. Methods and results: VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double-blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg kg−1), FVOO (500 mg kg−1), and FVOOT (500 mg kg−1; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat-soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol-enriched VOOs. These insights support the beneficial effects of OO and PC from different sources. Conclusion: Novel therapeutic strategies should increase HDL-cholesterol levels and enhance HDL functionality. The tailoring of phenol-enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals.
Áreas temáticas: Saúde coletiva; Química; Nutrição; Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; Food science & technology; Food science; Farmacia; Educação física; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biotechnology; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Direcció de correo del autor: ursula.catalan@urv.cat; anna.pedret@urv.cat; montse.giralt@urv.cat; rosamaria.valls@urv.cat; marta.romeu@urv.cat; rosa.sola@urv.cat
Fecha de alta del registro: 2025-01-28
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201800456
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 62 (16): e1800456-
Referencia de l'ítem segons les normes APA: Pedret, Anna; Fernandez-Castillejo, Sara; Valls, Rosa-Maria; Catalan, Ursula; Rubio, Laura; Romeu, Marta; Macia, Alba; Lopez de las Hazas, Maria Carme (2018). Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study. Molecular Nutrition & Food Research, 62(16), e1800456-. DOI: 10.1002/mnfr.201800456
DOI del artículo: 10.1002/mnfr.201800456
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications
Repositori URV