Autor según el artículo: Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Toledo, Estefania; Corella, Dolores; Salas-Salvado, Jordi; Cuenca-Royo, Aida; Vioque, Jesus; Romaguera, Dora; Alfredo Martinez, J; Warnberg, Julia; Lopez-Miranda, Jose; Estruch, Ramon; Bueno-Cavanillas, Aurora; Alonso-Gomez, Angel; Tur, Josep A; Tinahones, Francisco J; Serra-Majem, Lluis; Martin, Vicente; Lapetra, Jose; Vazquez, Clotilde; Pinto, Xavier; Vidal, Josep; Daimiel, Lidia; Gaforio, Jose J; Matia, Pilar; Ros, Emilio; Granero, Roser; Buil-Cosiales, Pilar; Barragan, Rocio; Bullo, Monica; Castaner, Olga; Garcia-de-la-Hera, Manoli; Yanez, Aina M; Abete, Itziar; Garcia-Rios, Antonio; Ruiz-Canela, Miguel; Diaz-Lopez, Andres; Jimenez-Murcia, Susana; Martinez-Gonzalez, Miguel A; De la Torre, Rafael; Fernandez-Aranda, Fernando
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica / Díaz López, Andres / Salas Salvadó, Jorge
Palabras clave: Women Risk People Mellitus Executive function Decline Cohort Adults
Resumen: This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Direcció de correo del autor: andres.diaz@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
Identificador del autor: 0000-0002-7500-5629 0000-0002-0218-7046 0000-0003-2700-7459
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41598-018-33843-8
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Scientific Reports. 8 (1): 16128-
Referencia de l'ítem segons les normes APA: Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Toledo, Estefania; Corella, Dolores; Salas-Salvado, Jordi; Cuenca-Royo, Aida; Vioque, Jesus; Romaguera, (2018). Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Scientific Reports, 8(1), 16128-. DOI: 10.1038/s41598-018-33843-8
DOI del artículo: 10.1038/s41598-018-33843-8
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications