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Donor Rhodium Carbenes by Retro-Buchner Reaction

  • Datos identificativos

    Identificador: imarina:4220472
    Autores:
    Mato, MauroEchavarren, Antonio M.
    Resumen:
    Rhodium carbenes are key intermediates in a range of cycloadditions and insertion reactions. Herein, we report the first generation of donor Rh-II carbenes by decarbenation of 7-substituted 1,3,5-cycloheptatrienes. This discovery unlocks an improved retro-Buchner-cyclopropanation sequence, a Si-H insertion reaction for a broad-scope synthesis of allylsilanes, and a new method for the vinylogation of aldehydes. The last strategy led to the development of an iterative synthesis of E-polyenes, and to the total synthesis of navenonesB and C.
  • Otros:

    Autor según el artículo: Mato, Mauro; Echavarren, Antonio M.;
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: ECHAVARREN PABLOS, ANTONIO / Mato Gómez, Mauro
    Palabras clave: Total synthesis Stereoselective functionalization Silanes Rhodium catalysis Retro-buchner reaction Insertion reactions In-situ generation H insertion Gold(i) carbenes Enantioselective cyclopropanation Diazo-compounds Catalyzed cyclopropanation Carbenes Building-blocks Breaking alarm pheromones silanes rhodium catalysis retro-buchner reaction carbenes
    Resumen: Rhodium carbenes are key intermediates in a range of cycloadditions and insertion reactions. Herein, we report the first generation of donor Rh-II carbenes by decarbenation of 7-substituted 1,3,5-cycloheptatrienes. This discovery unlocks an improved retro-Buchner-cyclopropanation sequence, a Si-H insertion reaction for a broad-scope synthesis of allylsilanes, and a new method for the vinylogation of aldehydes. The last strategy led to the development of an iterative synthesis of E-polyenes, and to the total synthesis of navenonesB and C.
    Áreas temáticas: Química Medicina ii Medicina i Materiais Interdisciplinar General medicine General chemistry Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Catalysis Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14337851
    Direcció de correo del autor: antoniomaria.echavarren@urv.cat
    Identificador del autor: 0000-0002-6418-7930
    Fecha de alta del registro: 2022-07-23
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1002/anie.201813512
    Referencia al articulo segun fuente origial: Angewandte Chemie (International Ed. Print). 58 (7): 2088-2092
    Referencia de l'ítem segons les normes APA: Mato, Mauro; Echavarren, Antonio M.; (2019). Donor Rhodium Carbenes by Retro-Buchner Reaction. Angewandte Chemie (International Ed. Print), 58(7), 2088-2092. DOI: 10.1002/anie.201813512
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1002/anie.201813512
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Catalysis,Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Total synthesis
    Stereoselective functionalization
    Silanes
    Rhodium catalysis
    Retro-buchner reaction
    Insertion reactions
    In-situ generation
    H insertion
    Gold(i) carbenes
    Enantioselective cyclopropanation
    Diazo-compounds
    Catalyzed cyclopropanation
    Carbenes
    Building-blocks
    Breaking alarm pheromones
    silanes
    rhodium catalysis
    retro-buchner reaction
    carbenes
    Química
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    General medicine
    General chemistry
    Farmacia
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemistry
    Catalysis
    Astronomia / física
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