Código de proyecto: 713679

Palabras clave: Incidence Heart diseases Fatty acids Cell membrane Body mass index

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Arteriosclerosis Thrombosis And Vascular Biology. 39 (4): 819-825

Referencia de l'ítem segons les normes APA: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Ca (2019). Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology, 39(4), 819-825. DOI: 10.1161/ATVBAHA.118.312073

Acrónimo: MFP-COFUND

Tipo de publicación: Journal Publications

Autor según el artículo: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M

Departamento: Bioquímica i Biotecnologia Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica / Muralidharan, Jananee / Salas Salvadó, Jorge

Resumen: Objective- To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. Approach and Results- This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28-0.69]), 59% (OR, 0.41 [95% CI, 0.25-0.65]), and 55% (OR, 0.45 [95% CI, 0.29-0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25-2.00]). Conclusions- Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids.

Áreas temáticas: Saúde coletiva Peripheral vascular disease Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 10498834

Direcció de correo del autor: jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de publicacion del artículo: 7 Feb 2019

Enlace a la fuente original: https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312073

Programa de financiación: European Union Horizon 2020

DOI del artículo: 10.1161/ATVBAHA.118.312073

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Acción del progama de financiación: Marie Skłodowska-Curie