e-ISSN: 2072-6643

Código de proyecto: 713679

Palabras clave:  inflammation Inflammation Fatty acids Cell membranes fatty acids cell membranes

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 11 (3):

Referencia de l'ítem segons les normes APA: Muralidharan J; Papandreou C; Sala-Vila A; Rosique-Esteban N; Fitó M; Estruch R; Martínez-González M; Corella D; Ros E; Razquín C; Castañer O; Salas-S (2019). Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis. Nutrients, 11(3), -. DOI: 10.3390/nu11030576

Acrónimo: MFP-COFUND

Página inicial: 576

Tipo de publicación: Journal Publications

Autor según el artículo: Muralidharan J; Papandreou C; Sala-Vila A; Rosique-Esteban N; Fitó M; Estruch R; Martínez-González M; Corella D; Ros E; Razquín C; Castañer O; Salas-Salvadó J; Bulló M

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica / Muralidharan, Jananee / ROSIQUE ESTEBAN, NÚRIA / Salas Salvadó, Jorge

Resumen: There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Direcció de correo del autor: jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de publicacion del artículo: 7 march 2019

Volumen de revista: 11

Enlace a la fuente original: https://www.mdpi.com/2072-6643/11/3/576

Programa de financiación: European Union Horizon 2020

DOI del artículo: 10.3390/nu11030576

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Acción del progama de financiación: Marie Skłodowska-Curie