Autor según el artículo: Pietzke, Matthias; Fernandez Arroyo, Salvador; Sumpton, David; Mackay, Gillian M.; Martin-Castillo, Begona; Camps, Jordi; Joven, Jorge; Menendez, Javier A.; Vazquez, Alexei; Pernas, Sonia; Dorca, Joan; Alvarez-Lopez, Isabel; Martinez, Susana; Manuel Perez-Garcia, Jose; Batista Lopez, Norberto; Rodriguez-Sanchez, Cesar A.; Amillano, Kepa; Dominguez Fernandez, Severina; Luque-Cabal, Maria; Morilla, Idoia; Vinas, Gemma; Cortes, Javier;METTEN Study Grp
Departamento: Medicina i Cirurgia
Autor/es de la URV: Camps Andreu, Jorge / Joven Maried, Jorge
Palabras clave: Serum metabolomics Hepatocellular-carcinoma Cancer serum metabolomics serum formate obesity nmr metabolomics analysis lung-cancer identify formate chemotherapy cancer biomarker
Resumen: BackgroundSerum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particular, the increasing incidence of obesity could become a significant confounding factor.MethodsHere we developed a multinomial classifier for the stratification of cancer, obesity and healthy phenotypes based on circulating glucose and formate levels. We quantified the classifier performance from the retrospective analysis of samples from breast cancer, lung cancer, obese individuals and healthy controls.ResultsWe discovered that circulating formate levels are significantly lower in breast and lung cancer patients than in healthy controls. However, the performance of a cancer classifier based on formate levels alone is limited because obese patients also have low serum formate levels. By introducing a multinomial classifier based on circulating glucose and formate levels, we were able to improve the classifier performance, reaching a true positive rate of 79% with a false positive rate of 8%.ConclusionsCirculating formate is reduced in HER2+ breast cancer, non-small cell lung cancer and highly obese patients relative to healthy controls. Further studies are required to determine the relevance of these observations in other cancer types and diseases.
Áreas temáticas: Oncology Endocrinology, diabetes and metabolism Ciencias sociales Cell biology Cancer research
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20493002
Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0195-x
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Cancer Metab. 7 (3): 3-
Referencia de l'ítem segons les normes APA: Pietzke, Matthias; Fernandez Arroyo, Salvador; Sumpton, David; Mackay, Gillian M.; Martin-Castillo, Begona; Camps, Jordi; Joven, Jorge; Menendez, Javi (2019). Stratification of cancer and diabetes based on circulating levels of formate and glucose. Cancer Metab, 7(3), 3-. DOI: 10.1186/s40170-019-0195-x
DOI del artículo: 10.1186/s40170-019-0195-x
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications