Autor según el artículo: Magyar, C; Gromiha, MM; Pujadas, G; Tusnady, GE; Simon, I;
Departamento: Bioquímica i Biotecnologia
e-ISSN: 1362-4962
Autor/es de la URV: Pujadas Anguiano, Gerard
Palabras clave: Long-range interactions Identification Folded proteins Centers
Resumen: Residues expected to play key roles in the stabilization of proteins [stabilizing residues (SRs)] are selected by combining several methods based mainly on the interactions of a given residue with its spatial, rather than its sequential neighborhood and by considering the evolutionary conservation of the residues. A residue is selected as a stabilizing residue if it has high surrounding hydrophobicity, high long-range order, high conservation score and if it belongs to a stabilization center. The definition of all these parameters and the thresholds used to identify the SRs are discussed in detail. The algorithm for identifying SRs was originally developed for TIM-barrel proteins [M. M. Gromiha, G. Pujadas, C. Magyar, S. Selvaraj, and I. Simon (2004), Proteins, 55, 316-329] and is now generalized for all proteins of known 3D structure. SRs could be applied in protein engineering and homology modeling and could also help to explain certain folds with significant stability. The SRide server is located at http://sride.enzim.hu.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Nutrição Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Genetics Farmacia Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0305-1048
Direcció de correo del autor: gerard.pujadas@urv.cat
Identificador del autor: 0000-0003-2598-8089
Página final: W305
Fecha de alta del registro: 2023-02-18
Volumen de revista: 33
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://academic.oup.com/nar/article/33/suppl_2/W303/2505549
Referencia al articulo segun fuente origial: Nucleic Acids Research. 33 (Supl 2): W303-W305
Referencia de l'ítem segons les normes APA: Magyar, C; Gromiha, MM; Pujadas, G; Tusnady, GE; Simon, I; (2005). SRide: a server for identifying stabilizing residues in proteins. Nucleic Acids Research, 33(Supl 2), W303-W305. DOI: 10.1093/nar/gki409
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1093/nar/gki409
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2005
Página inicial: W303
Tipo de publicación: Journal Publications
Repositori URV