Autor según el artículo: García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG.

Departamento: Bioquímica i Biotecnologia

e-ISSN: 1471-2148

Autor/es de la URV: Garcia Vallve, Santiago

Palabras clave: Type-18 promoter Multiple sequence alignment Lineages Life Keratinocytes Enhancer Cervical-cancer worldwide Cell-specific transcription

Resumen: Background: Papillomaviruses (PVs) infect stratified squamous epithelia in warm-blooded vertebrates and have undergone a complex evolutionary process. The control of the expression of the early ORFs in PVs depends on the binding of cellular and viral transcription factors to the upstream regulatory region (URR) of the virus. It is believed that there is a core of transcription factor binding sites (TFBS) common to all PVs, with additional individual differences, although most of the available information focuses only on a handful of viruses. Results: We have studied the URR of sixty-one PVs, covering twenty different hosts. We have predicted the TFBS present in the URR and analysed these results by principal component analysis and genetic algorithms. The number and nature of TFBS in the URR might be much broader than thus far described, and different PVs have different repertoires of TFBS. Conclusion: There are common fingerprints in the URR in PVs that infect primates, although the ancestors of these viruses diverged a long time ago. Additionally, there are obvious differences between the URR of alpha and beta PVs, despite these PVs infect similar histological cell types in the same host, i.e. human. A thorough analysis of the TFBS in the URR might provide crucial information about the differential biology of cancer-associated PVs.

Áreas temáticas: Zootecnia / recursos pesqueiros Química Medicina veterinaria Medicina i Interdisciplinar Geociências Genetics & heredity Evolutionary biology Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: santi.garcia-vallve@urv.cat

Identificador del autor: 0000-0002-0348-7497

Fecha de alta del registro: 2023-02-18

Volumen de revista: 6

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://bmcecolevol.biomedcentral.com/articles/10.1186/1471-2148-6-20

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Bmc Evolutionary Biology. 6

Referencia de l'ítem segons les normes APA: García-Vallvé S, Iglesias-Rozas JR, Alonso A, Bravo IG. (2006). Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region. Bmc Evolutionary Biology, 6(), -. DOI: 10.1186/1471-2148-6-20

DOI del artículo: 10.1186/1471-2148-6-20

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2006

Tipo de publicación: Journal Publications