Autor según el artículo: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica
Palabras clave: Prevention Plasma human Metabolomics Medium-chain Mediterranean diet Intervention Health Gut microbiota Ellagic acid Dicarboxylic-acids Consumption Cardiovascular-disease Biomarkers of nuts Adiposity metabolomics gut microbiota biomarkers of nuts adiposity
Resumen: To identify the most discriminant dietary biomarkers of nuts exposure in subjects with metabolic syndrome (MetS), and investigate the potential association between exposure and the severity of the MetS diagnostic traits.We applied the untargeted LC-ESI-qToF-MS-driven metabolomic workflow to explore the changes occurring in the plasma metabolome of MetS subjects following 12-wk intake of mixed nuts (30 g/d; nuts versus control groups). Urolithin A glucuronide was the most discriminative biomarker of nuts exposure, showing the highest predictive capacity (area under the ROC curve = 89.6% [80.8-98.4]) despite the interindividual variation expected for a host-microbial cometabolite. Furthermore, the detection of urolithin A glucuronide in plasma showed significant inverse correlation with basal abdominal adiposity (waist circumference: r = -0.550, p < 0.01; waist-hip ratio: r = -0.409, p < 0.05) and impaired glycemic control (fasting insulin: r = -0.414, p < 0.05; HOMA-IR: r = -0.417, p < 0.05). Significant changes in medium-chain dicarboxylic acids, recognized as alternative energy substrates that are particularly relevant in the case of glycemic control impairment, were also associated with nut consumption.Higher levels of utolithin A glucuronide are reported in subjects with less severe MetS traits, especially in females. We believe that this inverse correlation may be related with profile of gut microbial dysbiosis, recently associated to subjects with MetS.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: monica.bullo@urv.cat
Identificador del autor: 0000-0002-0218-7046
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201500549
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 59 (12): 2480-2490
Referencia de l'ítem segons les normes APA: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina (2015). Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. Molecular Nutrition & Food Research, 59(12), 2480-2490. DOI: 10.1002/mnfr.201500549
DOI del artículo: 10.1002/mnfr.201500549
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2015
Tipo de publicación: Journal Publications