Articles producció científica> Bioquímica i Biotecnologia

Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome

  • Datos identificativos

    Identificador: imarina:5129584
    Autores:
    Mora-Cubillos, XimenaTulipani, SaraGarcia-Aloy, MarBullo, MonicaTinahones, Francisco JAndres-Lacueva, Cristina
    Resumen:
    To identify the most discriminant dietary biomarkers of nuts exposure in subjects with metabolic syndrome (MetS), and investigate the potential association between exposure and the severity of the MetS diagnostic traits.We applied the untargeted LC-ESI-qToF-MS-driven metabolomic workflow to explore the changes occurring in the plasma metabolome of MetS subjects following 12-wk intake of mixed nuts (30 g/d; nuts versus control groups). Urolithin A glucuronide was the most discriminative biomarker of nuts exposure, showing the highest predictive capacity (area under the ROC curve = 89.6% [80.8-98.4]) despite the interindividual variation expected for a host-microbial cometabolite. Furthermore, the detection of urolithin A glucuronide in plasma showed significant inverse correlation with basal abdominal adiposity (waist circumference: r = -0.550, p < 0.01; waist-hip ratio: r = -0.409, p < 0.05) and impaired glycemic control (fasting insulin: r = -0.414, p < 0.05; HOMA-IR: r = -0.417, p < 0.05). Significant changes in medium-chain dicarboxylic acids, recognized as alternative energy substrates that are particularly relevant in the case of glycemic control impairment, were also associated with nut consumption.Higher levels of utolithin A glucuronide are reported in subjects with less severe MetS traits, especially in females. We believe that this inverse correlation may be related with profile of gut microbial dysbiosis, recently associated to subjects with MetS.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • Otros:

    Autor según el artículo: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bulló Bonet, Mònica
    Palabras clave: Prevention Plasma human Metabolomics Medium-chain Mediterranean diet Intervention Health Gut microbiota Ellagic acid Dicarboxylic-acids Consumption Cardiovascular-disease Biomarkers of nuts Adiposity metabolomics gut microbiota biomarkers of nuts adiposity
    Resumen: To identify the most discriminant dietary biomarkers of nuts exposure in subjects with metabolic syndrome (MetS), and investigate the potential association between exposure and the severity of the MetS diagnostic traits.We applied the untargeted LC-ESI-qToF-MS-driven metabolomic workflow to explore the changes occurring in the plasma metabolome of MetS subjects following 12-wk intake of mixed nuts (30 g/d; nuts versus control groups). Urolithin A glucuronide was the most discriminative biomarker of nuts exposure, showing the highest predictive capacity (area under the ROC curve = 89.6% [80.8-98.4]) despite the interindividual variation expected for a host-microbial cometabolite. Furthermore, the detection of urolithin A glucuronide in plasma showed significant inverse correlation with basal abdominal adiposity (waist circumference: r = -0.550, p < 0.01; waist-hip ratio: r = -0.409, p < 0.05) and impaired glycemic control (fasting insulin: r = -0.414, p < 0.05; HOMA-IR: r = -0.417, p < 0.05). Significant changes in medium-chain dicarboxylic acids, recognized as alternative energy substrates that are particularly relevant in the case of glycemic control impairment, were also associated with nut consumption.Higher levels of utolithin A glucuronide are reported in subjects with less severe MetS traits, especially in females. We believe that this inverse correlation may be related with profile of gut microbial dysbiosis, recently associated to subjects with MetS.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: monica.bullo@urv.cat
    Identificador del autor: 0000-0002-0218-7046
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201500549
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 59 (12): 2480-2490
    Referencia de l'ítem segons les normes APA: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina (2015). Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. Molecular Nutrition & Food Research, 59(12), 2480-2490. DOI: 10.1002/mnfr.201500549
    DOI del artículo: 10.1002/mnfr.201500549
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2015
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biotechnology,Food Science,Food Science & Technology
    Prevention
    Plasma human
    Metabolomics
    Medium-chain
    Mediterranean diet
    Intervention
    Health
    Gut microbiota
    Ellagic acid
    Dicarboxylic-acids
    Consumption
    Cardiovascular-disease
    Biomarkers of nuts
    Adiposity
    metabolomics
    gut microbiota
    biomarkers of nuts
    adiposity
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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