Autor según el artículo: Karapiperis, Christos; Kempf, Stefan J; Quintens, Roel; Azimzadeh, Omid; Vidal, Victoria Linares; Pazzaglia, Simonetta; Bazyka, Dimitry; Mastroberardino, Pier G; Scouras, Zacharias G; Tapio, Soile; Benotmane, Mohammed Abderrafi; Ouzounis, Christos A

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Linares Vidal, M. Victoria

Resumen: Background: The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies. Results: We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology. Conclusions: BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: .

Áreas temáticas: Structural biology Saúde coletiva Química Molecular biology Medicina veterinaria Medicina ii Medicina i Mathematical & computational biology Matemática / probabilidade e estatística Interdisciplinar Farmacia Engenharias iv Engenharias iii Computer science applications Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biotechnology & applied microbiology Biodiversidade Biochemistry Biochemical research methods Applied mathematics

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14712105

Direcció de correo del autor: mvictoria.linares@urv.cat

Identificador del autor: 0000-0003-4170-4197

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-1068-8

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Bmc Bioinformatics. 17 (212): 212-

Referencia de l'ítem segons les normes APA: Karapiperis, Christos; Kempf, Stefan J; Quintens, Roel; Azimzadeh, Omid; Vidal, Victoria Linares; Pazzaglia, Simonetta; Bazyka, Dimitry; Mastroberardi (2016). Brain Radiation Information Data Exchange (BRIDE): Integration of experimental data from low-dose ionising radiation research for pathway discovery. Bmc Bioinformatics, 17(212), 212-. DOI: 10.1186/s12859-016-1068-8

DOI del artículo: 10.1186/s12859-016-1068-8

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Tipo de publicación: Journal Publications