Articles producció científica> Bioquímica i Biotecnologia

Defining conditions for optimal inhibition of food intake in rats by a grape-seed derived proanthocyanidin extract

  • Datos identificativos

    Identificador: imarina:5130362
    Autores:
    Serrano, JoanCasanova-Marti, AngelaBlay, MayteTerra, XimenaArdevol, AnnaPinent, Montserrat
    Resumen:
    Food intake depends on homeostatic and non-homeostatic factors. In order to use grape seed proanthocyanidins (GSPE) as food intake limiting agents, it is important to define the key characteristics of their bioactivity within this complex function. We treated rats with acute and chronic treatments of GSPE at different doses to identify the importance of eating patterns and GSPE dose and the mechanistic aspects of GSPE. GSPE-induced food intake inhibition must be reproduced under non-stressful conditions and with a stable and synchronized feeding pattern. A minimum dose of around 350 mg GSPE/kg body weight (BW) is needed. GSPE components act by activating the Glucagon-like peptide-1 (GLP-1) receptor because their effect is blocked by Exendin 9-39. GSPE in turn acts on the hypothalamic center of food intake control probably because of increased GLP-1 production in the intestine. To conclude, GSPE inhibits food intake through GLP-1 signaling, but it needs to be dosed under optimal conditions to exert this effect.
  • Otros:

    Autor según el artículo: Serrano, Joan; Casanova-Marti, Angela; Blay, Mayte; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat
    Departamento: Bioquímica i Biotecnologia
    e-ISSN: 2072-6643
    Autor/es de la URV: Ardévol Grau, Anna / Blay Olivé, Maria Teresa / CASANOVA MARTÍ, ANGELA / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
    Palabras clave: Synchronicity Proanthocyanidins Hypothalamus Glp-1 Food intake Dose proanthocyanidins hypothalamus glp-1 food intake dose
    Resumen: Food intake depends on homeostatic and non-homeostatic factors. In order to use grape seed proanthocyanidins (GSPE) as food intake limiting agents, it is important to define the key characteristics of their bioactivity within this complex function. We treated rats with acute and chronic treatments of GSPE at different doses to identify the importance of eating patterns and GSPE dose and the mechanistic aspects of GSPE. GSPE-induced food intake inhibition must be reproduced under non-stressful conditions and with a stable and synchronized feeding pattern. A minimum dose of around 350 mg GSPE/kg body weight (BW) is needed. GSPE components act by activating the Glucagon-like peptide-1 (GLP-1) receptor because their effect is blocked by Exendin 9-39. GSPE in turn acts on the hypothalamic center of food intake control probably because of increased GLP-1 production in the intestine. To conclude, GSPE inhibits food intake through GLP-1 signaling, but it needs to be dosed under optimal conditions to exert this effect.
    Grupo de investigación: Bioactivitat Molecular dels Aliments
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: thttps://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Direcció de correo del autor: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat montserrat.pinent@urv.cat
    Identificador del autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378
    Fecha de alta del registro: 2024-10-19
    Volumen de revista: 8
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2072-6643/8/10/652
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nutrients. 8 (10): 652-
    Referencia de l'ítem segons les normes APA: Serrano, Joan; Casanova-Marti, Angela; Blay, Mayte; Terra, Ximena; Ardevol, Anna; Pinent, Montserrat (2016). Defining conditions for optimal inhibition of food intake in rats by a grape-seed derived proanthocyanidin extract. Nutrients, 8(10), 652-. DOI: 10.3390/nu8100652
    DOI del artículo: 10.3390/nu8100652
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Synchronicity
    Proanthocyanidins
    Hypothalamus
    Glp-1
    Food intake
    Dose
    proanthocyanidins
    hypothalamus
    glp-1
    food intake
    dose
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
  • Documentos:

  • Cerca a google

    Search to google scholar