Autor según el artículo: Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I.
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Nogués Llort, Maria Rosa
Palabras clave: Wistar kyoto rat Liver protein regulation High-fat, high-sucrose diet Grape polyphenols Fish oils Bioactive compounds liver protein regulation high-fat, high-sucrose diet grape polyphenols fish oils bioactive compounds
Resumen: This study considered the physiological modulation of liver proteins due to the supplementation with fish oils under two dietary backgrounds: standard or high in fat and sucrose (HFHS), and their combination with grape polyphenols. By using a quantitative proteomics approach, we showed that the capacity of the supplements for regulating proteins depended on the diet; namely, 10 different proteins changed into standard diets, while 45 changed into the HFHS diets and only scarcely proteins were found altered in common. However, in both contexts, fish oils were the main regulatory force, although the addition of polyphenols was able to modulate some fish oils' effects. Moreover, we demonstrated the ability of fish oils and their combination with grape polyphenols in improving biochemical parameters and reducing lipogenesis and glycolysis enzymes, enhancing fatty acid beta-oxidation and insulin signaling and ameliorating endoplasmic reticulum stress and protein oxidation when they are included in an unhealthy diet.
Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Molecular biology Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Endocrinology, diabetes and metabolism Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology Biochemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09552863
Direcció de correo del autor: mariarosa.nogues@urv.cat
Identificador del autor: 0000-0003-4626-5672
Página final: 97
Fecha de alta del registro: 2023-02-18
Volumen de revista: 41
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0955286316302674?via%3Dihub
Referencia al articulo segun fuente origial: Journal Of Nutritional Biochemistry. 41 84-97
Referencia de l'ítem segons les normes APA: Méndez L., Ciordia S., Fernández M., Juárez S., Ramos A., Pazos M., Gallardo J., Torres J., Nogués M., Medina I. (2017). Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics. Journal Of Nutritional Biochemistry, 41(), 84-97. DOI: 10.1016/j.jnutbio.2016.12.005
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.jnutbio.2016.12.005
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Página inicial: 84
Tipo de publicación: Journal Publications
Repositori URV