Articles producció científica> Química Analítica i Química Orgànica

A novel wireless paper-based potentiometric platform for monitoring glucose in blood

  • Datos identificativos

    Identificador: imarina:5131273
    Autores:
    Cánovas RParrilla M.Blondeau P.Andrade F.J.
    Resumen:
    A novel low-cost, compact and sensitive paper-based platform for the accurate monitoring of glucose in biological fluids is presented. Paper-based working and reference electrodes are combined to build a whole potentiometric cell, which also fits a sampling module for simple and fast determination of glucose in a single drop of blood. The working electrode is built using a platinized filter paper coated with a Nafion membrane that entraps the enzyme glucose oxidase; the reference electrode is made by casting a polyvinylbutyral-based membrane onto a conductive paper. The system works by detecting the hydrogen peroxide generated as a result of the enzymatic reaction. Selectivity is achieved due to the permselective behaviour of Nafion, while a significant enhancement of the sensitivity is reached by exploiting the Donnan-coupled formal potential. Under optimum conditions, a sensitivity of −95.9 ± 4.8 mV per decade in the 0.3-3 mM range is obtained. Validation of the measurements has been performed against standard methods in human serum and blood. Final integration with a wireless reader allows for truly in situ measurements with a less than 2 minute procedure including a two-point calibration, washing and measurement. This low-cost analytical device opens up new prospects for rapid diagnostic results in nonlaboratory settings.
  • Otros:

    Código de proyecto: CTQ2013-46404-R
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Lab On A Chip. 17 (14): 2500-2507
    Referencia de l'ítem segons les normes APA: Cánovas R; Parrilla M.; Blondeau P.; Andrade F.J. (2017). A novel wireless paper-based potentiometric platform for monitoring glucose in blood. Lab On A Chip, 17(14), 2500-2507. DOI: 10.1039/c7lc00339k
    Acrónimo: 'Plataformas electroquímicas descentralizadas'
    Tipo de publicación: Journal Publications
    Autor según el artículo: Cánovas R; Parrilla M.; Blondeau P.; Andrade F.J.
    Departamento: Química Analítica i Química Orgànica
    Acrónimo 2: HOMESENS
    Autor/es de la URV: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon
    Resumen: A novel low-cost, compact and sensitive paper-based platform for the accurate monitoring of glucose in biological fluids is presented. Paper-based working and reference electrodes are combined to build a whole potentiometric cell, which also fits a sampling module for simple and fast determination of glucose in a single drop of blood. The working electrode is built using a platinized filter paper coated with a Nafion membrane that entraps the enzyme glucose oxidase; the reference electrode is made by casting a polyvinylbutyral-based membrane onto a conductive paper. The system works by detecting the hydrogen peroxide generated as a result of the enzymatic reaction. Selectivity is achieved due to the permselective behaviour of Nafion, while a significant enhancement of the sensitivity is reached by exploiting the Donnan-coupled formal potential. Under optimum conditions, a sensitivity of −95.9 ± 4.8 mV per decade in the 0.3-3 mM range is obtained. Validation of the measurements has been performed against standard methods in human serum and blood. Final integration with a wireless reader allows for truly in situ measurements with a less than 2 minute procedure including a two-point calibration, washing and measurement. This low-cost analytical device opens up new prospects for rapid diagnostic results in nonlaboratory settings.
    Acción del programa de financiación 2: Proyecto de I+D
    Áreas temáticas: Química Nanoscience and nanotechnology Nanoscience & nanotechnology Materiais Interdisciplinar Instruments & instrumentation General medicine General chemistry Farmacia Engenharias iv Engenharias ii Chemistry, multidisciplinary Chemistry, analytical Chemistry (miscellaneous) Chemistry (all) Biotecnología Biomedical engineering Bioengineering Biochemistry Biochemical research methods Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14730189
    Direcció de correo del autor: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat
    Identificador del autor: 0000-0003-1331-5055 0000-0003-1199-2837
    Codigo del proyecto 2: CTQ2016-77128-R
    Programa de financiación 2: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
    Enlace a la fuente original: https://pubs.rsc.org/en/content/articlelanding/2017/lc/c7lc00339k#!divAbstract
    Programa de financiación: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
    DOI del artículo: 10.1039/c7lc00339k
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Acción del progama de financiación: Proyecto de investigación
  • Palabras clave:

    Biochemical Research Methods,Biochemistry,Bioengineering,Biomedical Engineering,Chemistry (Miscellaneous),Chemistry, Analytical,Chemistry, Multidisciplinary,Instruments & Instrumentation,Nanoscience & Nanotechnology,Nanoscience and Nanotechnology
    Química
    Nanoscience and nanotechnology
    Nanoscience & nanotechnology
    Materiais
    Interdisciplinar
    Instruments & instrumentation
    General medicine
    General chemistry
    Farmacia
    Engenharias iv
    Engenharias ii
    Chemistry, multidisciplinary
    Chemistry, analytical
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Biomedical engineering
    Bioengineering
    Biochemistry
    Biochemical research methods
    Astronomia / física
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