Metal‐Free Synthesis of N‐Aryl Amides using Organocatalytic Ring‐Opening Aminolysis of Lactones

Identificador:  imarina:5131443

Handle: https://hdl.handle.net/20.500.11797/imarina5131443

Autores:  Guo, WS; Gómez, JE; Martínez-Rodríguez, L; Bandeira, NAG; Bo, C; Kleij, AW

Resumen:
Catalytic ring-opening of bio-sourced non-strained lactones with aromatic amines can offer a straightforward, 100% atom-economical, and sustainable pathway towards relevant N-aryl amide scaffolds. Herein, the first general, metal-free, and highly efficient N-aryl amide formation is reported from poorly reactive aromatic amines and non-strained lactones under mild operating conditions using an organic bicyclic guanidine catalyst. This protocol has high application potential as exemplified by the formal syntheses of drug-relevant molecules.