Autor según el artículo: Cabrera A., Vives M., Molina A., París M., Raga E., Sánchez A., Sabench F., Del Castillo D.
Departamento: Medicina i Cirurgia
Autor/es de la URV: Del Castillo Déjardin, Daniel / MOLINA LÓPEZ, ALICIA
Palabras clave: Sleeve gastrectomy Glucagon Ghrelin Gastric plication Experimental surgery Bariatric surgery glucagon ghrelin gastric plication
Resumen: © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Aim: Laparoscopic gastric plication (LGP) is a bariatric surgical technique based on the anatomical principles of laparoscopic sleeve gastrectomy (LSG), but its effects on the metabolic profile are still uncertain. The aim of our study is to compare the changes in weight, metabolic parameters and gastric histology following intervention by gastric plication (GP) and sleeve gastrectomy (SG) in an experimental model of obesity. Methods: To conduct the study, 32 8-week-old male Sprague-Dawley rats (Charles River®) were fattened by means of a cafeteria diet and randomly assigned to the following experimental groups: group 1: GP (n = 12); group 2: SG (n = 12) and group 3: sham (n = 8). Results: Unlike the SG group, the GP group attained the weight of the sham group at the end of the experiment (week 16). The GP group continued to eat more cafeteria diet than the SG group. In addition, the SG group achieved better glycaemic control than the GP group. Significantly higher plasma ghrelin levels were observed at week 16 in the GP group than in the SG group (2.29 ± 0.5 vs 1.07 ± 0.4, p < 0.05), which also occurred for the glucagon plasmatic levels (62.71 ± 36.2 vs 24.63 ± 9.3, p < 0.05). Conclusions: GP is not as effective as SG and cannot be considered a metabolic surgery due to observed hormonal variations. The animals subjected to a GP continued to have a high appetite for the cafeteria diet unlike the animals submitted to an SG. Hormonal mechanisms possibly related to glucagon and ghrelin may be involved in this metabolic response.
Áreas temáticas: Surgery Saúde coletiva Psicología Odontología Nutrition and dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09608923
Direcció de correo del autor: danieldel.castillo@urv.cat
Identificador del autor: 0000-0003-0456-3102 0000-0001-7024-7824
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
Enlace a la fuente original: https://link.springer.com/article/10.1007/s11695-018-3340-7
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Obesity Surgery. 28 (10): 3259-3267
Referencia de l'ítem segons les normes APA: Cabrera A., Vives M., Molina A., París M., Raga E., Sánchez A., Sabench F., Del Castillo D. (2018). Gastric Plication and Sleeve Gastrectomy in an Experimental Model of Obesity: New Insights into Weight Loss, Intake and Metabolic Results. Obesity Surgery, 28(10), 3259-3267. DOI: 10.1007/s11695-018-3340-7
DOI del artículo: 10.1007/s11695-018-3340-7
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications