Articles producció científica> Bioquímica i Biotecnologia

The Implication of the Brain Insulin Receptor in Late Onset Alzheimer's Disease Dementia.

  • Datos identificativos

    Identificador: imarina:5132023
    Handle: http://hdl.handle.net/20.500.11797/imarina5132023
  • Autores:

    Folch J, Ettcheto M, Busquets O, Sánchez-López E, Castro-Torres RD, Verdaguer E, Manzine PR, Poor SR, García ML, Olloquequi J, Beas-Zarate C, Auladell C, Camins A.
  • Otros:

    Autor según el artículo: Folch J, Ettcheto M, Busquets O, Sánchez-López E, Castro-Torres RD, Verdaguer E, Manzine PR, Poor SR, García ML, Olloquequi J, Beas-Zarate C, Auladell C, Camins A.
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Folch Lopez, Jaume
    Palabras clave: Type 2 diabetes Tau Neurodegeneration Insulin resistance Insulin receptor Cognition Amyloid Alzheimer’s tau insulin resistance insulin receptor cognition amyloid alzheimer’s
    Resumen: Alzheimer's disease (AD) is progressive neurodegenerative disorder characterized by brain accumulation of the amyloid β peptide (Aβ), which form senile plaques, neurofibrillary tangles (NFT) and, eventually, neurodegeneration and cognitive impairment. Interestingly, epidemiological studies have described a relationship between type 2 diabetes mellitus (T2DM) and this pathology, being one of the risk factors for the development of AD pathogenesis. Information as it is, it would point out that, impairment in insulin signalling and glucose metabolism, in central as well as peripheral systems, would be one of the reasons for the cognitive decline. Brain insulin resistance, also known as Type 3 diabetes, leads to the increase of Aβ production and TAU phosphorylation, mitochondrial dysfunction, oxidative stress, protein misfolding, and cognitive impairment, which are all hallmarks of AD. Moreover, given the complexity of interlocking mechanisms found in late onset AD (LOAD) pathogenesis, more data is being obtained. Recent evidence showed that Aβ42 generated in the brain would impact negatively on the hypothalamus, accelerating the 'peripheral' symptomatology of AD. In this situation, Aβ42 production would induce hypothalamic dysfunction that would favour peripheral hyperglycaemia due to down regulation of the liver insulin receptor. The objective of this review is to discuss the existing evidence supporting the concept that brain insulin resistance and altered glucose metabolism play an important role in pathogenesis of LOAD. Furthermore, we discuss AD treatment approaches targeting insulin signalling using anti-diabetic drugs and mTOR inhibitors.
    Áreas temáticas: Saúde coletiva Química Pharmacology & pharmacy Pharmaceutical science Molecular medicine Medicina ii Interdisciplinar Farmacia Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Chemistry, medicinal Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14248247
    Direcció de correo del autor: jaume.folch@urv.cat
    Identificador del autor: 0000-0002-5051-8858
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/1424-8247/11/1/11
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Pharmaceuticals. 11 (1):
    Referencia de l'ítem segons les normes APA: Folch J, Ettcheto M, Busquets O, Sánchez-López E, Castro-Torres RD, Verdaguer E, Manzine PR, Poor SR, García ML, Olloquequi J, Beas-Zarate C, Auladell (2018). The Implication of the Brain Insulin Receptor in Late Onset Alzheimer's Disease Dementia.. Pharmaceuticals, 11(1), -. DOI: 10.3390/ph11010011
    DOI del artículo: 10.3390/ph11010011
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry, Medicinal,Drug Discovery,Molecular Medicine,Pharmaceutical Science,Pharmacology & Pharmacy
    Type 2 diabetes
    Tau
    Neurodegeneration
    Insulin resistance
    Insulin receptor
    Cognition
    Amyloid
    Alzheimer’s
    tau
    insulin resistance
    insulin receptor
    cognition
    amyloid
    alzheimer’s
    Saúde coletiva
    Química
    Pharmacology & pharmacy
    Pharmaceutical science
    Molecular medicine
    Medicina ii
    Interdisciplinar
    Farmacia
    Drug discovery
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Chemistry, medicinal
    Biotecnología
    Biodiversidade
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