Autor según el artículo: Rodriguez-Gallego, Esther; Gomez, Josep; Domingo, Pere; Ferrando-Martinez, Sara; Peraire, Joaquim; Vilades, Consuelo; Veloso, Sergi; Lopez-Dupla, Miguel; Beltran-Debon, Raul; Alba, Veronica; Vargas, Montserrat; Castellano, Alfonso J; Leal, Manuel; Maria Pacheco, Yolanda; Ruiz-Mateos, Ezequiel; Gutierrez, Felix; Vidal, Francesc; Rull, Anna
Departamento: Bioquímica i Biotecnologia; Medicina i Cirurgia
Autor/es de la URV: Beltrán Debón, Raúl Alejandro / Gómez Alvarez, Josep / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / RULL AIXA, ANNA / SIRVENT CALVERA, JUAN JOSÉ / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria
Palabras clave: Triglycerides; Predictive value of tests; Nmr; Middle aged; Metabolomics; Metabolome; Male; Lipoproteins; Lipids; Humans; Hiv infections; Hiv; Female; Dyslipidemias; Dyslipidemia; Cholesterol; Art therapy; Anti-retroviral agents; Adult; metabolomics; lipoproteins; lipids; hiv; dyslipidemia; art therapy
Resumen: © 2018 The Authors Background and aims: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. Methods: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months. Univariate and multivariate analyses were performed to evaluate the predictive power of NMR spectroscopy. Results: VLDL-metabolism (including VLDL lipid concentrations, sizes, and particle numbers), total triglycerides and lactate levels resulted in good classifiers of dyslipidemia (AUC 0.903). Total particles/HDL-P ratio was significantly higher in ART-associated dyslipidemia compared to ART-normolipidemia (p = 0.001). Large VLDL-Ps were positively associated with both LDL-triglycerides (ρ 0.682, p < 0.001) and lactate concentrations (ρ 0.416, p < 0.001), the last one a marker of mitochondrial low oxidative capacity. Conclusions: Our data suggest that circulating metabolites have better predictive values for HIV/ART-related dyslipidemia onset than do the biochemical markers associated with conventional lipid measurements. NMR identifies changes in VLDL-P, lactate and LDL-TG as potential clinical markers of baseline HIV-dyslipidemia predisposition. Differences in circulating metabolomics, especially differences in particle size, are indicators of important derangements of mitochondrial function that are linked to ART-related dyslipidemia.
Áreas temáticas: Saúde coletiva; Psicología; Peripheral vascular disease; Odontología; Nutrição; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciência de alimentos; Ciência da computação; Cardiology and cardiovascular medicine; Cardiac & cardiovascular systems; Biotecnología; Antropologia / arqueologia
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00219150
Direcció de correo del autor: josep.gomez@urv.cat; joaquim.peraire@urv.cat; consuelo.vilades@urv.cat; francesc.vidal@urv.cat; raul.beltran@urv.cat; jesusmiguel.lopez@urv.cat
Fecha de alta del registro: 2025-02-18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.atherosclerosis-journal.com/article/S0021-9150(18)30182-5/fulltext
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Atherosclerosis. 273 28-36
Referencia de l'ítem segons les normes APA: Rodriguez-Gallego, Esther; Gomez, Josep; Domingo, Pere; Ferrando-Martinez, Sara; Peraire, Joaquim; Vilades, Consuelo; Veloso, Sergi; Lopez-Dupla, Migu (2018). Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy. Atherosclerosis, 273(), 28-36. DOI: 10.1016/j.atherosclerosis.2018.04.008
DOI del artículo: 10.1016/j.atherosclerosis.2018.04.008
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications
Repositori URV