Articles producció científica> Medicina i Cirurgia

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.

  • Datos identificativos

    Identificador: imarina:5132423
    Handle: http://hdl.handle.net/20.500.11797/imarina5132423
  • Autores:

    Serena C, Ceperuelo-Mallafré V, Keiran N, Queipo-Ortuño MI, Bernal R, Gomez-Huelgas R, Urpi-Sarda M, Sabater M, Pérez-Brocal V, Andrés-Lacueva C, Moya A, Tinahones FJ, Fernández-Real JM, Vendrell J, Fernández-Veledo S.
  • Otros:

    Autor según el artículo: Serena C, Ceperuelo-Mallafré V, Keiran N, Queipo-Ortuño MI, Bernal R, Gomez-Huelgas R, Urpi-Sarda M, Sabater M, Pérez-Brocal V, Andrés-Lacueva C, Moya A, Tinahones FJ, Fernández-Real JM, Vendrell J, Fernández-Veledo S.
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Fernandez Veledo, Sonia / Vendrell Ortega, Juan José
    Palabras clave: Sp nov. Serum zonulin Receptor gpr91 Metabolites Mediterranean diet Marker Glucose Emerging role Chain fatty-acids Adipose-tissue
    Resumen: © 2018 The Author(s). Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.
    Áreas temáticas: Microbiology Medicina ii Interdisciplinar Geociências Engenharias iv Engenharias iii Ecology, evolution, behavior and systematics Ecology Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 17517362
    Direcció de correo del autor: sonia.fernandez@urv.cat juanjose.vendrell@urv.cat
    Identificador del autor: 0000-0003-2906-3788 0000-0002-6994-6115
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.nature.com/articles/s41396-018-0068-2
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Isme Journal. 12 (7): 1642-1657
    Referencia de l'ítem segons les normes APA: Serena C, Ceperuelo-Mallafré V, Keiran N, Queipo-Ortuño MI, Bernal R, Gomez-Huelgas R, Urpi-Sarda M, Sabater M, Pérez-Brocal V, Andrés-Lacueva C, Moya (2018). Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.. Isme Journal, 12(7), 1642-1657. DOI: 10.1038/s41396-018-0068-2
    DOI del artículo: 10.1038/s41396-018-0068-2
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Ecology,Ecology, Evolution, Behavior and Systematics,Microbiology
    Sp nov.
    Serum zonulin
    Receptor gpr91
    Metabolites
    Mediterranean diet
    Marker
    Glucose
    Emerging role
    Chain fatty-acids
    Adipose-tissue
    Microbiology
    Medicina ii
    Interdisciplinar
    Geociências
    Engenharias iv
    Engenharias iii
    Ecology, evolution, behavior and systematics
    Ecology
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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