Autor según el artículo: Werner M, Auth T, Beales P, Fleury J, Höök F, Kress H, Van Lehn R, Müller M, Petrov E, Sarkisov L, Sommer J, Baulin V

Departamento: Enginyeria Química

Autor/es de la URV: Baulin, Vladimir

Palabras clave: Theileria-parva Surface-properties Receptor-mediated endocytosis Protein corona Poly(ethylene glycol) Nanoparticles Lipid-membranes Drug-delivery Computer-simulation Cellular uptake

Resumen: Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors' current understanding of the biological world. This conceptual mismatch makes it challenging to create synthetic nanomaterials that possess desired functions in biological media. In many biologically relevant applications, nanomaterials must enter the cell interior to perform their functions. An essential transport barrier is the cell-protecting plasma membrane and hence the understanding of its interaction with nanomaterials is a fundamental task in biotechnology. The authors present open questions in the field of nanomaterial interactions with biological membranes, including: how physical mechanisms and molecular forces acting at the nanoscale restrict or inspire design options; which levels of complexity to include next in computational and experimental models to describe how nanomaterials cross barriers via passive or active processes; and how the biological media and protein corona interfere with nanomaterial functionality. In this Perspective, the authors address these questions with the aim of offering guidelines for the development of next-generation nanomaterials that function in biological media.

Áreas temáticas: Química Physics and astronomy (miscellaneous) Physics and astronomy (all) Odontología Materials science, biomaterials Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General physics and astronomy General medicine General materials science General chemistry General biochemistry,genetics and molecular biology Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biophysics Biomaterials Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 15594106

Direcció de correo del autor: vladimir.baulin@urv.cat

Identificador del autor: 0000-0003-2086-4271

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://avs.scitation.org/doi/pdf/10.1116/1.5022145

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Biointerphases. 13 (2): 028501-

Referencia de l'ítem segons les normes APA: Werner M, Auth T, Beales P, Fleury J, Höök F, Kress H, Van Lehn R, Müller M, Petrov E, Sarkisov L, Sommer J, Baulin V (2018). Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context. Biointerphases, 13(2), 028501-. DOI: 10.1116/1.5022145

DOI del artículo: 10.1116/1.5022145

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications