Autor según el artículo: Ardid-Ruiz A, Ibars M, Mena P, Del Rio D, Muguerza B, Bladé C, Arola L, Aragonès G, Suárez M.

Departamento: Bioquímica i Biotecnologia

e-ISSN: 2072-6643

Autor/es de la URV: Aragonès Bargalló, Gerard / Arola Ferrer, Luis Maria / IBARS SERRA, MARIA / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel

Palabras clave: Sirtuin Obesity Microbiota Metabolites Leptin resistance Cafeteria diet obesity microbiota metabolites leptin resistance cafeteria diet

Resumen: Bioactive compounds such as polyphenols have increased in importance in recent years, and among them, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has generated great interest as an anti-obesity agent. Recent investigations have highlighted the importance of leptin signaling in lipid metabolism in peripheral organs. The aims of this study were (1) to investigate whether resveratrol can reduce fat accumulation in peripheral tissues by increasing their leptin sensitivity and (2) to identify which resveratrol-derived circulating metabolites are potentially involved in these metabolic effects. Serum leptin levels and the leptin signaling pathway were assessed in diet-induced obese rats. Moreover, serum metabolites of resveratrol were studied by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MSn). The daily consumption of 200 mg/kg of resveratrol, but not doses of 50 and 100 mg/kg, reduced body weight and fat accumulation in obese rats and restored leptin sensitivity in the periphery. These effects were due to increases in sirtuin 1 activity in the liver, leptin receptors in muscle and protection against endoplasmic reticulum (ER)-stress in adipose tissue. In general, the resveratrol metabolites associated with these beneficial effects were derived from both phase II and microbiota metabolism, although only those derived from microbiota increased proportionally with the administered dose of resveratrol. In conclusion, resveratrol reversed leptin resistance caused by diet-induced obesity in peripheral organs using tissue-specific mechanisms.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Direcció de correo del autor: gerard.aragones@urv.cat begona.muguerza@urv.cat lluis.arola@urv.cat manuel.suarez@urv.cat

Identificador del autor: 0000-0001-7384-8588 0000-0003-2767-1974 0000-0003-0122-8253

Fecha de alta del registro: 2023-02-22

Volumen de revista: 10

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/10/11/1757

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 10 (11):

Referencia de l'ítem segons les normes APA: Ardid-Ruiz A, Ibars M, Mena P, Del Rio D, Muguerza B, Bladé C, Arola L, Aragonès G, Suárez M. (2018). Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation. Nutrients, 10(11), -. DOI: 10.3390/nu10111757

DOI del artículo: 10.3390/nu10111757

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications