Autor según el artículo: Casanova E, Salvadó J, Crescenti A, Gibert-Ramos A.
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: CASANOVA VALLVÉ, ESTER / Salvadó Rovira, Maria Josepa
Palabras clave: Oxidative stress Obesity Muscle Epigallocatechin gallate Cell signaling obesity muscle epigallocatechin gallate cell signaling
Resumen: Obesity is associated with the hypertrophy and hyperplasia of adipose tissue, affecting the healthy secretion profile of pro- and anti-inflammatory adipokines. Increased influx of fatty acids and inflammatory adipokines from adipose tissue can induce muscle oxidative stress and inflammation and negatively regulate myocyte metabolism. Muscle has emerged as an important mediator of homeostatic control through the consumption of energy substrates, as well as governing systemic signaling networks. In muscle, obesity is related to decreased glucose uptake, deregulation of lipid metabolism, and mitochondrial dysfunction. This review focuses on the effect of epigallocatechin-gallate (EGCG) on oxidative stress and inflammation, linked to the metabolic dysfunction of skeletal muscle in obesity and their underlying mechanisms. EGCG works by increasing the expression of antioxidant enzymes, by reversing the increase of reactive oxygen species (ROS) production in skeletal muscle and regulating mitochondria-involved autophagy. Moreover, EGCG increases muscle lipid oxidation and stimulates glucose uptake in insulin-resistant skeletal muscle. EGCG acts by modulating cell signaling including the NF-kB, AMP-activated protein kinase (AMPK), and mitogen-activated protein kinase (MAPK) signaling pathways, and through epigenetic mechanisms such as DNA methylation and histone acetylation.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14220067
Direcció de correo del autor: mariajosepa.salvado@urv.cat
Identificador del autor: 0000-0003-3883-3326
Fecha de alta del registro: 2023-02-18
Volumen de revista: 20
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/1422-0067/20/3/532
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 20 (3): 532-
Referencia de l'ítem segons les normes APA: Casanova E, Salvadó J, Crescenti A, Gibert-Ramos A. (2019). Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review. International Journal Of Molecular Sciences, 20(3), 532-. DOI: 10.3390/ijms20030532
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.3390/ijms20030532
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Página inicial: Article number 532
Tipo de publicación: Journal Publications