Autor según el artículo: Casanova E, Salvadó J, Crescenti A, Gibert-Ramos A.

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: CASANOVA VALLVÉ, ESTER / Salvadó Rovira, Maria Josepa

Palabras clave: Oxidative stress Obesity Muscle Epigallocatechin gallate Cell signaling obesity muscle epigallocatechin gallate cell signaling

Resumen: Obesity is associated with the hypertrophy and hyperplasia of adipose tissue, affecting the healthy secretion profile of pro- and anti-inflammatory adipokines. Increased influx of fatty acids and inflammatory adipokines from adipose tissue can induce muscle oxidative stress and inflammation and negatively regulate myocyte metabolism. Muscle has emerged as an important mediator of homeostatic control through the consumption of energy substrates, as well as governing systemic signaling networks. In muscle, obesity is related to decreased glucose uptake, deregulation of lipid metabolism, and mitochondrial dysfunction. This review focuses on the effect of epigallocatechin-gallate (EGCG) on oxidative stress and inflammation, linked to the metabolic dysfunction of skeletal muscle in obesity and their underlying mechanisms. EGCG works by increasing the expression of antioxidant enzymes, by reversing the increase of reactive oxygen species (ROS) production in skeletal muscle and regulating mitochondria-involved autophagy. Moreover, EGCG increases muscle lipid oxidation and stimulates glucose uptake in insulin-resistant skeletal muscle. EGCG acts by modulating cell signaling including the NF-kB, AMP-activated protein kinase (AMPK), and mitogen-activated protein kinase (MAPK) signaling pathways, and through epigenetic mechanisms such as DNA methylation and histone acetylation.

Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14220067

Direcció de correo del autor: mariajosepa.salvado@urv.cat

Identificador del autor: 0000-0003-3883-3326

Fecha de alta del registro: 2023-02-18

Volumen de revista: 20

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1422-0067/20/3/532

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 20 (3): 532-

Referencia de l'ítem segons les normes APA: Casanova E, Salvadó J, Crescenti A, Gibert-Ramos A. (2019). Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review. International Journal Of Molecular Sciences, 20(3), 532-. DOI: 10.3390/ijms20030532

DOI del artículo: 10.3390/ijms20030532

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Página inicial: Article number 532

Tipo de publicación: Journal Publications