Autor según el artículo: Garcia-Algar, Manuel; Fernandez-Carrascal, Ana; Olano-Daza, Ana; Guerrini, Luca; Feliu, Neus; Parak, Wolfgang J.; Guimera, Roger; Garcia-Rico, Eduardo; Alvarez-Puebla, Ramon A.;

Departamento: Enginyeria Química

Autor/es de la URV: Alvarez Puebla, Ramon Angel / Guimera Manrique, Roger

Palabras clave: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu

Resumen: In this manuscript, we demonstrate the applicability of a metabolic liquid biopsy for the monitoring and staging of patients with lung cancer. This method provides an unbiased detection strategy to establish a more precise correlation between CTC quantification and the actual burden of disease, therefore improving the accuracy of staging based on current imaging techniques. Also, by applying statistical analysis techniques and probabilistic models to the metabolic status and distribution of peripheral blood mononuclear cell (PBMC) populations 'perturbed' by the presence of CTCs, a new category of adaptive metabolic pattern biomarker (AMPB) is described and unambiguously correlated to the different clinical stages of the patients. In fact, this strategy allows for classification of different categories of disease within a single stage (stage IV) before computed tomography (CT) and positron emission tomography (PET) scans and with lower uncertainty.

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2397-768X

Direcció de correo del autor: roger.guimera@urv.cat ramon.alvarez@urv.cat

Identificador del autor: 0000-0002-3597-4310 0000-0003-4770-5756

Fecha de alta del registro: 2023-09-24

Volumen de revista: 2

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.nature.com/articles/s41698-018-0059-9

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: 2 16-

Referencia de l'ítem segons les normes APA: Garcia-Algar, Manuel; Fernandez-Carrascal, Ana; Olano-Daza, Ana; Guerrini, Luca; Feliu, Neus; Parak, Wolfgang J.; Guimera, Roger; Garcia-Rico, Eduardo (2018). Adaptive metabolic pattern biomarker for disease monitoring and staging of lung cancer with liquid biopsy. Npj Precision Oncology, 2(), 16-. DOI: 10.1038/s41698-018-0059-9

DOI del artículo: 10.1038/s41698-018-0059-9

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Página inicial: Article number 16

Tipo de publicación: Journal Publications