Autor según el artículo: Halu, Arda; De Domenico, Manlio; Arenas, Alex; Sharma, Amitabh
Departamento: Enginyeria Informàtica i Matemàtiques
Autor/es de la URV: Arenas Moreno, Alejandro / DE DOMENICO, MANLIO
Palabras clave: Systems biology Phenotype Ontology Online mendelian inheritance Maps Humans Genotype Gene regulatory networks Disease Computational biology and bioinformatics Computational biology Community structure Biology
Resumen: Untangling the complex interplay between phenotype and genotype is crucial to the effective characterization and subtyping of diseases. Here we build and analyze the multiplex network of 779 human diseases, which consists of a genotype-based layer and a phenotype-based layer. We show that diseases with common genetic constituents tend to share symptoms, and uncover how phenotype information helps boost genotype information. Moreover, we offer a flexible classification of diseases that considers their molecular underpinnings alongside their clinical manifestations. We detect cohesive groups of diseases that have high intra-group similarity at both the molecular and the phenotypic level. Inspecting these disease communities, we demonstrate the underlying pathways that connect diseases mechanistically. We observe monogenic disorders grouped together with complex diseases for which they increase the risk factor. We propose potentially new disease associations that arise as a unique feature of the information flow within and across the two layers.
Áreas temáticas: Modeling and simulation Mathematical & computational biology General biochemistry,genetics and molecular biology Drug discovery Computer science applications Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Applied mathematics
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20567189
Direcció de correo del autor: alexandre.arenas@urv.cat
Identificador del autor: 0000-0003-0937-0334
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41540-019-0092-5
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Npj Syst Biol Appl. 5 (UNSP 15): 15-15
Referencia de l'ítem segons les normes APA: Halu, Arda; De Domenico, Manlio; Arenas, Alex; Sharma, Amitabh (2019). The multiplex network of human diseases. Npj Syst Biol Appl, 5(UNSP 15), 15-15. DOI: 10.1038/s41540-019-0092-5
DOI del artículo: 10.1038/s41540-019-0092-5
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications