Autor según el artículo: Pascual-Serrano A; Bladé C; Suárez M; Arola-Arnal A

Departamento: Bioquímica i Biotecnologia

e-ISSN: 1422-0067

Autor/es de la URV: Arola Arnal, Anna / PASCUAL SERRANO, AÏDA / Suárez Recio, Manuel

Palabras clave: Resveratrol Ppar-gamma Polyphenols Polyphenol Mice Metabolic syndrome Hypertrophy Hyperplasia High-fat Gene-expression Flavonoids Brown Adipogenesis Adipocyte Activated receptor-gamma 3t3-l1 cells hypertrophy hyperplasia flavonoids adipogenesis adipocyte

Resumen: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. The development of metabolic complications associated with obesity has been correlated with a failure of white adipose tissue (WAT) to expand. Our group has previously reported that a 12-week administration of grape seed proanthocyanidin extract (GSPE) together with an obesogenic diet mitigated the development of cardiometabolic complications in rats. Using the same cohort of animals, we aim to elucidate whether the prevention of cardiometabolic complications by proanthocyanidins is produced by a healthier expansion of visceral WAT and/or an induction of the browning of WAT. For this, adipocyte size and number in retroperitoneal WAT (rWAT) were determined by histological analyses, and the gene expression levels of markers of adipogenesis, browning, and WAT functionality were quantified by RT-qPCR. The long-term administration of GSPE together with an obesogenic diet expanded rWAT via an increase in the adipocyte number and a preventive decrease in the adipocyte size in a dose-dependent manner. At the molecular level, GSPE seems to induce WAT adipogenesis through the upregulation of peroxisome proliferator-activated receptor (Pparγ) in a Sirtuin 1 (Sirt1)-dependent manner. In conclusion, the healthier visceral WAT expansion induced by proanthocyanidins supplementation may explain the improvement in the cardiometabolic risks associated with obesogenic diets.

Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14220067

Direcció de correo del autor: anna.arola@urv.cat manuel.suarez@urv.cat

Identificador del autor: 0000-0001-6529-1345 0000-0003-0122-8253

Fecha de alta del registro: 2023-02-22

Volumen de revista: 19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1422-0067/19/9/2632

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 19 (9):

Referencia de l'ítem segons les normes APA: Pascual-Serrano A; Bladé C; Suárez M; Arola-Arnal A (2018). Grape seed proanthocyanidins improve white adipose tissue expansion during diet-induced obesity development in rats. International Journal Of Molecular Sciences, 19(9), -. DOI: 10.3390/ijms19092632

DOI del artículo: 10.3390/ijms19092632

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications