Articles producció científica> Bioquímica i Biotecnologia

Virgin olive oil (unfiltered) extract contains peptides and possesses ACE inhibitory and antihypertensive activity

  • Datos identificativos

    Identificador: imarina:5611130
  • Autores:

    Alcaide-Hidalgo JM
    Margalef M
    Bravo FI
    Muguerza B
    López-Huertas E
  • Otros:

    Autor según el artículo: Alcaide-Hidalgo JM; Margalef M; Bravo FI; Muguerza B; López-Huertas E
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Muguerza Marquínez, Maria Begoña
    Palabras clave: Spontaneously hypertensive rats Peptides Olive oil Hypertension Ace peptides olive oil hypertension ace
    Resumen: © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Background & aims: The peptide and protein composition of olive oil is mostly unknown and the few studies available have not focused on the study of its low molecular weight peptides. We hypothesised that olive oil could naturally contain low molecular weight peptides with antihypertensive effect. Methods: We produced virgin olive oil (unfiltered, var. Picual) and obtained a water-soluble peptide extract. We fractionated the peptide extract by FPLC and studied its angiotensin converting enzyme (ACE) inhibitory activity. We studied the antihypertensive effect of olive oil peptides on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) using an animal model of hypertension (spontaneously hypertensive rats, SHR). The animals were randomly distributed into 3 study groups (n = 8 per group) and received an oral dose of olive oil peptides (0.425 mg/kg of BW), or a dose of Captopril (50 mg/kg of BW) or water. SBP and DBP were registered in the rats before administration and a at 2, 4, 6, 8, 24 and 48 h post-administration of the corresponding dose. Results: The peptide extract and FPLC purified fractions possessed angiotensin converting enzyme (ACE) inhibitory activity. Acute oral administration of olive oil water-soluble extract produced an average blood pressure reduction of 10 mmHg at 4 h (P < 0.01) and reached a maximum antihypertensive effect of 20 mmHg at 6 h, compared with baseline. Conclusion: Unfiltered virgin olive oil contains peptides and a water-soluble extract obtained from this oil possesses ACE inhibitory activity and in vivo antihypertensive effect.
    Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    ISSN: 02615614
    Direcció de correo del autor: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat
    Identificador del autor: 0000-0002-6468-3088 0000-0001-7384-8588
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0261561419302274
    Referencia al articulo segun fuente origial: Clinical Nutrition. 39 (4): 1242-1249
    Referencia de l'ítem segons les normes APA: Alcaide-Hidalgo JM; Margalef M; Bravo FI; Muguerza B; López-Huertas E (2020). Virgin olive oil (unfiltered) extract contains peptides and possesses ACE inhibitory and antihypertensive activity. Clinical Nutrition, 39(4), 1242-1249. DOI: 10.1016/j.clnu.2019.05.016
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1016/j.clnu.2019.05.016
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Spontaneously hypertensive rats
    Peptides
    Olive oil
    Hypertension
    Ace
    peptides
    olive oil
    hypertension
    ace
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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