Autor según el artículo: Rovira, Joaquim; Angeles Martinez, Maria; Prasad Sharma, Raju; Espuis, Teresa; Nadal, Marti; Kumar, Vikas; Costopoulou, Danae; Vassiliadou, Irene; Leondiadis, Leondios; Domingo, Jose L; Schuhmacher, Marta
Departamento: Ciències Mèdiques Bàsiques Enginyeria Química
Autor/es de la URV: Domingo Roig, José Luis / Kumar, Vikas / Martínez Rodríguez, María Ángeles / Nadal Lomas, Martí / Rovira Solano, Joaquim / Schuhmacher Ansuategui, Marta
Palabras clave: Spain Serum concentrations Prenatal exposure delayed effects Prenatal exposure Pregnancy Polyfluoroalkyl substances Plasma Pfos Pfoa Persistent organic pollutants Perfluorooctanoic acid Perfluoroalkyl substances Perfluorinated compounds Pbpk modeling Maternal exposure Humans Health-risks Fluorocarbons Female Environmental exposure Drinking-water Dietary intake Dietary exposure Cord blood Child Caprylates Birth cohort Alkanesulfonic acids plasma pfos pfoa pbpk modeling dietary intake cord blood
Resumen: © 2019 Elsevier Inc. This study was aimed at assessing the prenatal exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in a cohort of pregnant women living in Reus (Tarragona County, Catalonia, Spain). These chemicals were biomonitored in maternal plasma during the first trimester of pregnancy, at delivery, and in cord blood. The dietary exposure of PFOS and PFOA was estimated by using questionnaires of food frequency and water intake, as well as data on food levels previously reported in the same area. In addition, the exposure through air inhalation and indoor dust ingestion was also calculated. Finally, a physiologically-based pharmacokinetic (PBPK) model was applied in order to establish the prenatal exposure of the fetus/child and to adjust exposure assessment vs. biomonitoring results. Probabilistic calculations of fetal exposure were performed by forward internal dosimetry and Monte-Carlo simulation. Mean plasma levels of PFOA were 0.45, 0.13 and 0.12 ng/mL at the first trimester, at delivery and in cord plasma, while those of PFOS were 2.93, 2.21, and 1.17 ng/mL, respectively. Traces of PFOS were found in all samples in the trimester and at delivery, and almost in all cord blood samples. Transplacental transfers of PFOS and PFOA were estimated to be around 70% and 60%, respectively. A temporal decrease trend in plasma levels of PFOS and PFOA was noticed, when comparing current values with data obtained 10 years ago in the same area. In agreement with many other studies, dietary intake was the main route of exposure to PFOS and PFOA in our cohort of pregnant women. It is an important issue to establish the exposure in critical windows periods such as fetal development to perfluoroalkylated substances, but also to other endocrine disrupting chemicals.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00139351
Direcció de correo del autor: vikas.kumar@urv.cat mangeles.martinez@urv.cat joaquim.rovira@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat marta.schuhmacher@urv.cat
Identificador del autor: 0000-0002-9795-5967 0000-0001-8595-3772 0000-0003-4399-6138 0000-0001-6647-9470 0000-0002-0217-4827 0000-0003-4381-2490
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Environmental Research. 175 384-392
Referencia de l'ítem segons les normes APA: Rovira, Joaquim; Angeles Martinez, Maria; Prasad Sharma, Raju; Espuis, Teresa; Nadal, Marti; Kumar, Vikas; Costopoulou, Danae; Vassiliadou, Irene; Leo (2019). Prenatal exposure to PFOS and PFOA in a pregnant women cohort of Catalonia, Spain. Environmental Research, 175(), 384-392. DOI: 10.1016/j.envres.2019.05.040
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications
Repositori URV