Autor según el artículo: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica / Rabassa Soler, Antonio / Salas Salvadó, Jorge
Palabras clave: Waist circumference Transcriptome Subcutaneous fat Post-transcriptional regulation Overweight Obesity Micrornas Male Humans High-throughput Glycemic index Female Diet, fat-restricted Diet Carbohydrates Caloric restriction Body weight Adult Adiposity obesity high-throughput diet carbohydrates
Resumen: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) microRNA (miRNA) profile. Methods and results: 6-month parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in eight randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects. None of the miRNAs showed significant changes between the intervention groups. However, changes in some of them correlated with changes in biochemical and anthropometric variables. Stratifying our population according to tertiles of percentage change in body weight (BW), we observed a significant down-regulation of miR-210 in those subjects in Tertile 1 as compared to Tertile 3. When our population was stratified by tertiles of waist circumference, miR-132, miR-29a, miR-34a, and miR-378 were found to be significantly down-regulated, in T2 compared to T3. Furthermore, when stratified by tertiles of fat mass, we also observed the significant down-regulation of miR-132 in T1. Conclusion: The macronutrient composition of a calorie-restricted diet does not affect the expression of the miRNAs analyzed, while changes in adiposity play a primary regulatory role.
Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Direcció de correo del autor: antonio.rabassa@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
Identificador del autor: 0000-0002-0218-7046 0000-0003-2700-7459
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201700594
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 62 (2): 1700594-
Referencia de l'ítem segons les normes APA: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica (2018). Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in Adiposity-Related Parameters. Molecular Nutrition & Food Research, 62(2), 1700594-. DOI: 10.1002/mnfr.201700594
DOI del artículo: 10.1002/mnfr.201700594
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications