Articles producció científica> Bioquímica i Biotecnologia

Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in Adiposity-Related Parameters

  • Datos identificativos

    Identificador: imarina:5671682
    Autores:
    Giardina, SimonaHernandez-Alonso, PabloSalas-Salvado, JordiRabassa-Soler, AntoniBullo, Monica
    Resumen:
    © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) microRNA (miRNA) profile. Methods and results: 6-month parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in eight randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects. None of the miRNAs showed significant changes between the intervention groups. However, changes in some of them correlated with changes in biochemical and anthropometric variables. Stratifying our population according to tertiles of percentage change in body weight (BW), we observed a significant down-regulation of miR-210 in those subjects in Tertile 1 as compared to Tertile 3. When our population was stratified by tertiles of waist circumference, miR-132, miR-29a, miR-34a, and miR-378 were found to be significantly down-regulated, in T2 compared to T3. Furthermore, when stratified by tertiles of fat mass, we also observed the significant down-regulation of miR-132 in T1. Conclusion: The macronutrient composition of a calorie-restricted diet does not affect the expression of the miRNAs analyzed, while changes in adiposity play a primary regulatory role.
  • Otros:

    Autor según el artículo: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Bulló Bonet, Mònica / Rabassa Soler, Antonio / Salas Salvadó, Jorge
    Palabras clave: Waist circumference Transcriptome Subcutaneous fat Post-transcriptional regulation Overweight Obesity Micrornas Male Humans High-throughput Glycemic index Female Diet, fat-restricted Diet Carbohydrates Caloric restriction Body weight Adult Adiposity obesity high-throughput diet carbohydrates
    Resumen: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) microRNA (miRNA) profile. Methods and results: 6-month parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in eight randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects. None of the miRNAs showed significant changes between the intervention groups. However, changes in some of them correlated with changes in biochemical and anthropometric variables. Stratifying our population according to tertiles of percentage change in body weight (BW), we observed a significant down-regulation of miR-210 in those subjects in Tertile 1 as compared to Tertile 3. When our population was stratified by tertiles of waist circumference, miR-132, miR-29a, miR-34a, and miR-378 were found to be significantly down-regulated, in T2 compared to T3. Furthermore, when stratified by tertiles of fat mass, we also observed the significant down-regulation of miR-132 in T1. Conclusion: The macronutrient composition of a calorie-restricted diet does not affect the expression of the miRNAs analyzed, while changes in adiposity play a primary regulatory role.
    Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Direcció de correo del autor: antonio.rabassa@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
    Identificador del autor: 0000-0002-0218-7046 0000-0003-2700-7459
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201700594
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 62 (2): 1700594-
    Referencia de l'ítem segons les normes APA: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica (2018). Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in Adiposity-Related Parameters. Molecular Nutrition & Food Research, 62(2), 1700594-. DOI: 10.1002/mnfr.201700594
    DOI del artículo: 10.1002/mnfr.201700594
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biotechnology,Food Science,Food Science & Technology
    Waist circumference
    Transcriptome
    Subcutaneous fat
    Post-transcriptional regulation
    Overweight
    Obesity
    Micrornas
    Male
    Humans
    High-throughput
    Glycemic index
    Female
    Diet, fat-restricted
    Diet
    Carbohydrates
    Caloric restriction
    Body weight
    Adult
    Adiposity
    obesity
    high-throughput
    diet
    carbohydrates
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
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