Autor según el artículo: Schreiber, Elga; Garcia, Tania; Sharma, Raju Prasad; Torrente, Margarita; Domingo, Jose Luis; Gomez, Mercedes
Departamento: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia
Autor/es de la URV: Domingo Roig, José Luis / Garcia Soldevila, Tània / Gómez Arnaiz, María Mercedes / Torrente Torné, Margarita
Palabras clave: Trace-elements Testis Testes Redox status Rats, sprague-dawley Rats Pregnant-women Peanut oil Partition-coefficients Parabens Paraben concentrations Oxidative stress N-butylparaben (n-butp) Male Lipid peroxidation In-vitro Glutathione reductase Glutathione peroxidase Glutathione Endocrine disruptors Catalase Calcium Butylparaben Butyl paraben Bisphenol-a Biomarkers Arachis Antioxidants Antioxidant system Animals testes rats peanut oil oxidative stress
Resumen: © 2019 Elsevier Ltd This study was aimed at determining if oxidative stress imbalance in testes of rats occurs after n-butylparaben (n-ButP) exposure. Young male Sprague-Dawley rats were subcutaneously treated with n-ButP during one spermatogenic cycle (57 days) at 0 (control-oil), 150, 300 and 600 mg/kg/d with peanut oil as vehicle. A non-vehicle control group was also included. Antioxidant enzyme activities (superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase) and levels of reduced and oxidized glutathione were measured in testes. Lipid peroxidation and H2O2 concentrations were also assessed. Results showed an increase of oxidative stress in oil-treated groups, excepting 600 mg/kg/d, suggesting oxidative stress due to peanut oil. A possible antioxidant effect due to n-ButP and its metabolites was suggested at 600 mg/kg/d, the only group not showing oxidative stress. An increase of calcium concentration in testes was also observed. On the other hand, a physiologically-based pharmacokinetic (PBPK) model was developed and the concentrations of n-ButP and its metabolites were simulated in plasma and testes. The peak concentration (Cmax) in testes was found slightly higher than that in plasma. The current results indicate that peanut oil can cause oxidative stress while high doses of n-ButP can act as antioxidant agent in testes.
Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Direcció de correo del autor: joseluis.domingo@urv.cat margarita.torrente@urv.cat
Identificador del autor: 0000-0001-6647-9470 0000-0002-8901-6345
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S027869151930362X?via%3Dihub#!
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 131 (110573): 110573-
Referencia de l'ítem segons les normes APA: Schreiber, Elga; Garcia, Tania; Sharma, Raju Prasad; Torrente, Margarita; Domingo, Jose Luis; Gomez, Mercedes (2019). Oxidative stress in testes of rats exposed to n-butylparaben. Food And Chemical Toxicology, 131(110573), 110573-. DOI: 10.1016/j.fct.2019.110573
DOI del artículo: 10.1016/j.fct.2019.110573
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications
Repositori URV