Autor según el artículo: Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C, Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V

Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques Psicologia

Autor/es de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria / Canals Sans, Josefa / Escribano Subías, Joaquín / Hernandez Martinez, Carmen / Iglesias Vazquez, Lucia / RIBOT SERRA, BLANCA / Voltas Moreso, Núria

Palabras clave: Supplementation Serum ferritin Requirements Prevention Prevalence Neurodevelopment Metaanalysis Lactation Iron supplementation Growth Formula Development Deficiency anemia Children Child health Anthropometry iron supplementation development child health anthropometry

Resumen: Since iron plays an important role in several physiological processes, its deficiency but also overload may harm the development of children. The aim was to assess the effect of iron-fortified milk on the iron biochemical status and the neurodevelopment of children at 12 months of age.Randomized controlled trial conducted in 133 Spanish children, allocated in two groups to receive formula milk fortified with 1.2 or 0.4 mg/100 mL of iron between 6 and 12 months of age. Psychomotor (PDI) and Mental (MDI) Development Index were assessed by the Bayley Scales before and after the intervention. Maternal obstetrical and psychosocial variables were recorded. The biochemical iron status of children was measured and data about breastfeeding, anthropometry and infections during the first year of life were registered.Children fortified with 1.2 mg/100 mL of iron, compared with 0.4 mg/100 mL, showed higher serum ferritin (21.5 vs 19.1 μg/L) and lower percentage of both iron deficiency (1.1 to 5.9% vs 3.8 to 16.7%, respectively, from 6 to 12 months) and iron deficiency anemia (4.3 to 1.1% vs 0 to 4.2%, respectively, from 6 to 12 months) at the end of the intervention. No significant differences were found on neurodevelopment from 6 to 12 months between children who received high dose of Fe compared with those who received low dose.Despite differences on the iron status were observed, there were no effects on neurodevelopment of well-nourished children in a developed country after iron supplementation with doses within dietary recommendations. Follow-up studies are needed to test for long-term neurodevelopmental improvement.Retrospectively registered in ClinicalTrials.gov with the ID: NCT02690675.

Áreas temáticas: Saúde coletiva Psicología Planejamento urbano e regional / demografia Pediatrics, perinatology and child health Pediatrics Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14712431

Direcció de correo del autor: nuria.aranda@urv.cat lucia.iglesias@urv.cat nuria.voltas@urv.cat victoria.arija@urv.cat joaquin.escribano@urv.cat josefa.canals@urv.cat carmen.hernandez@urv.cat lucia.iglesias@urv.cat

Identificador del autor: 0000-0001-9708-747X 0000-0001-7131-4144 0000-0001-8855-0282 0000-0002-1758-0975 0000-0002-5041-459X 0000-0002-6209-9558 0000-0001-6328-8679 0000-0001-7131-4144

Fecha de alta del registro: 2023-02-22

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-019-1679-0#Abs1

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Bmc Pediatrics. 19 (1): 315-315

Referencia de l'ítem segons les normes APA: Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C, Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V (2019). Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial. Bmc Pediatrics, 19(1), 315-315. DOI: https://doi.org/10.1186/s12887-019-1679-0

DOI del artículo: 10.1186/s12887-019-1679-0

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Tipo de publicación: Journal Publications