Articles producció científica> Medicina i Cirurgia

Preoperative circulating succinate levels as a biomarker for diabetes remission after bariatric surgery

  • Datos identificativos

    Identificador: imarina:5871169
    Handle: http://hdl.handle.net/20.500.11797/imarina5871169
  • Autores:

    Ceperuelo-Mallafre V
    Llaurado G
    Keiran N
    Benaiges E
    Astiarraga B
    Martinez L
    Pellitero S
    Gonzalez-Clemente JM
    Rodriguez A
    Fernandez-Real JM
    Lecube A
    Megia A
    Vilarrasa N
    Vendrell J
    Fernandez-Veledo S
  • Otros:

    Autor según el artículo: Ceperuelo-Mallafre V; Llaurado G; Keiran N; Benaiges E; Astiarraga B; Martinez L; Pellitero S; Gonzalez-Clemente JM; Rodriguez A; Fernandez-Real JM; Lecube A; Megia A; Vilarrasa N; Vendrell J; Fernandez-Veledo S
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    Autor/es de la URV: Ceperuelo Mallafré, Maria Victoria / Domínguez Porfirio, Brenno / Fernandez Veledo, Sonia / Megía Colet, Ana / Vendrell Ortega, Juan José
    Palabras clave: Validation study Succinic acid Sleeve gastrectomy Roux-en-y gastric bypass Risk factor Remission Randomized controlled trial Prospective study Preoperative period Predictive value Prediction Obesity Non insulin dependent diabetes mellitus Middle aged Male Laparoscopic greater curvature plication Human Follow up Female Controlled study Cohort analysis Clinical article Biological marker Biochemical analysis Bariatric surgery Article Anthropometric parameters Adult
    Resumen: © 2019 by the American Diabetes Association. OBJECTIVE To determine the potential use of baseline circulating succinate to predict type 2 diabetes remission after bariatric surgery. RESEARCH DESIGN AND METHODS Forty-five obese patients with diabetes were randomly assigned to Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or laparoscopic greater curvature plication. Anthropometric parameters were evaluated, and a complete biochemical analysis including circulating serum succinate concentrations was performed at baseline and 1 year after surgery. The results were externally validated in a second cohort including 88 obese patients with diabetes assigned to RYGB or SG based on clinical criteria. RESULTS Succinate baseline concentrations were an independent predictor of diabetes remission after bariatric surgery. Patients achieving remission after 1 year hadlower levels of baseline succinate (47.8 [37.6-64.6] mmol/L vs. 64.1 [52.5-82.9] μmol/L; P = 0.018). Moreover, succinate concentrations were significantly decreased 1 year after surgery (58.9 [46.4-82.4] μmol/L vs. 46.0 [35.8-65.3] mmol/L, P = 0.005). In multivariate analysis, the best logistic regression model showed that baseline succinate (odds ratio [OR] 11.3, P = 0.031) and the type of surgery (OR 26.4, P = 0.010) were independently associated with remission. The C-statistic for this model was 0.899 (95% CI 0.809-0.989) in the derivation cohort, which significantly improved the prediction of remission compared with current available scores, and 0.729 (95% CI 0.612-0.846) in the validation cohort. Interestingly, patients had a different response to the type of surgery according to baseline succinate, with significant differences in remission rates. CONCLUSIONS Circulating succinate is reduced after bariatric surgery. Baseline succinate levels have predictive value for diabetes remission independently of previously described presurgical factors and improve upon the current available scores to predict remission.
    Áreas temáticas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 01495992
    Direcció de correo del autor: brenno.dominguez@urv.cat sonia.fernandez@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat ana.megia@urv.cat
    Identificador del autor: 0000-0003-2216-8974 0000-0003-2906-3788 0000-0002-4460-9761 0000-0002-6994-6115 0000-0002-5101-9452
    Fecha de alta del registro: 2023-10-07
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://care.diabetesjournals.org/content/42/10/1956
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Diabetes Care. 42 (10): 1956-1965
    Referencia de l'ítem segons les normes APA: Ceperuelo-Mallafre V; Llaurado G; Keiran N; Benaiges E; Astiarraga B; Martinez L; Pellitero S; Gonzalez-Clemente JM; Rodriguez A; Fernandez-Real JM; L (2019). Preoperative circulating succinate levels as a biomarker for diabetes remission after bariatric surgery. Diabetes Care, 42(10), 1956-1965. DOI: 10.2337/dc19-0114
    DOI del artículo: 10.2337/dc19-0114
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Advanced and Specialized Nursing,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Validation study
    Succinic acid
    Sleeve gastrectomy
    Roux-en-y gastric bypass
    Risk factor
    Remission
    Randomized controlled trial
    Prospective study
    Preoperative period
    Predictive value
    Prediction
    Obesity
    Non insulin dependent diabetes mellitus
    Middle aged
    Male
    Laparoscopic greater curvature plication
    Human
    Follow up
    Female
    Controlled study
    Cohort analysis
    Clinical article
    Biological marker
    Biochemical analysis
    Bariatric surgery
    Article
    Anthropometric parameters
    Adult
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Antropologia / arqueologia
    Advanced and specialized nursing
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