Autor según el artículo: Ceperuelo-Mallafre, Victoria; Llaurado, Gemma; Keiran, Noelia; Benaiges, Ester; Astiarraga, Brenno; Martinez, Laia; Pellitero, Silvia; Miguel Gonzalez-Clemente, Jose; Rodriguez, Amaia; Manuel Fernandez-Real, Jose; Lecube, Albert; Megia, Ana; Vilarrasa, Nuria; Vendrell, Joan; Fernandez-Veledo, Sonia
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Benaiges Moragrega, Ester / Ceperuelo Mallafré, Maria Victoria / Domínguez Porfirio, Brenno / Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Martínez Salamero, Luis / Megía Colet, Ana / Vendrell Ortega, Juan José
Palabras clave: Weight loss Validation study Treatment outcome Succinic acid Sleeve gastrectomy Roux-en-y gastric bypass Risk factor Remission induction Remission Randomized controlled trial Prospective study Prognosis Preoperative period Predictive value Prediction Obesity Non insulin dependent diabetes mellitus Middle aged Male Laparoscopy Laparoscopic greater curvature plication Humans Human Follow up Female Diabetes mellitus, type 2 Controlled study Cohort studies Cohort analysis Clinical article Biomarkers Biological marker Biochemical analysis Bariatric surgery Article Anthropometric parameters Aged Adult
Resumen: © 2019 by the American Diabetes Association. OBJECTIVE To determine the potential use of baseline circulating succinate to predict type 2 diabetes remission after bariatric surgery. RESEARCH DESIGN AND METHODS Forty-five obese patients with diabetes were randomly assigned to Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or laparoscopic greater curvature plication. Anthropometric parameters were evaluated, and a complete biochemical analysis including circulating serum succinate concentrations was performed at baseline and 1 year after surgery. The results were externally validated in a second cohort including 88 obese patients with diabetes assigned to RYGB or SG based on clinical criteria. RESULTS Succinate baseline concentrations were an independent predictor of diabetes remission after bariatric surgery. Patients achieving remission after 1 year hadlower levels of baseline succinate (47.8 [37.6-64.6] mmol/L vs. 64.1 [52.5-82.9] μmol/L; P = 0.018). Moreover, succinate concentrations were significantly decreased 1 year after surgery (58.9 [46.4-82.4] μmol/L vs. 46.0 [35.8-65.3] mmol/L, P = 0.005). In multivariate analysis, the best logistic regression model showed that baseline succinate (odds ratio [OR] 11.3, P = 0.031) and the type of surgery (OR 26.4, P = 0.010) were independently associated with remission. The C-statistic for this model was 0.899 (95% CI 0.809-0.989) in the derivation cohort, which significantly improved the prediction of remission compared with current available scores, and 0.729 (95% CI 0.612-0.846) in the validation cohort. Interestingly, patients had a different response to the type of surgery according to baseline succinate, with significant differences in remission rates. CONCLUSIONS Circulating succinate is reduced after bariatric surgery. Baseline succinate levels have predictive value for diabetes remission independently of previously described presurgical factors and improve upon the current available scores to predict remission.
Áreas temáticas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01495992
Direcció de correo del autor: brenno.dominguez@urv.cat victoria.ceperuelo@urv.cat luis.martinez@urv.cat ester.benaiges@estudiants.urv.cat ester.benaiges@estudiants.urv.cat sonia.fernandez@urv.cat ana.megia@urv.cat jvortega@iispv.cat
Identificador del autor: 0000-0003-2216-8974 0000-0002-4460-9761 0000-0003-3344-9501 0000-0003-2906-3788 0000-0002-5101-9452 0000-0002-6994-6115
Fecha de alta del registro: 2025-03-03
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Diabetes Care. 42 (10): 1956-1965
Referencia de l'ítem segons les normes APA: Ceperuelo-Mallafre, Victoria; Llaurado, Gemma; Keiran, Noelia; Benaiges, Ester; Astiarraga, Brenno; Martinez, Laia; Pellitero, Silvia; Miguel Gonzalez (2019). Preoperative circulating succinate levels as a biomarker for diabetes remission after bariatric surgery. Diabetes Care, 42(10), 1956-1965. DOI: 10.2337/dc19-0114
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications
Repositori URV