Autor según el artículo: Miro-Blanch J, Yanes O

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica

Autor/es de la URV: Miró Blanch, Joan / Yanes Torrado, Óscar

Palabras clave: Transplantation Transcription Posttranslational modifications Open chromatin Omics Microbiota Metabolomics Metabolism Impact Histones Epigenetics Donor feces Dna Diet-induced obesity Bacteria Acetylation

Resumen: Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Molecular medicine Medicina veterinaria Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16648021

Direcció de correo del autor: oscar.yanes@urv.cat joan.miro@estudiants.urv.cat

Identificador del autor: 0000-0003-3695-7157 0000-0003-3179-0554

Fecha de alta del registro: 2023-05-21

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fgene.2019.00638/full

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Frontiers In Genetics. 10 (JUL): 638-638

Referencia de l'ítem segons les normes APA: Miro-Blanch J, Yanes O (2019). Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism. Frontiers In Genetics, 10(JUL), 638-638. DOI: 10.3389/fgene.2019.00638

DOI del artículo: 10.3389/fgene.2019.00638

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Tipo de publicación: Journal Publications