Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism

  • Datos identificativos

    Identificador: imarina:5873597
    Autores:
    Miro-Blanch, JoanYanes, Oscar
    Resumen:
    Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity.
  • Otros:

    Autor según el artículo: Miro-Blanch, Joan; Yanes, Oscar
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Miró Blanch, Joan / Yanes Torrado, Óscar
    Palabras clave: Transplantation Transcription Posttranslational modifications Open chromatin Omics Microbiota Metabolomics Metabolism Impact Histones Epigenetics Donor feces Dna Diet-induced obesity Bacteria Acetylation
    Resumen: Gut microbiota communities have coevolved for millions of years in a symbiotic relationship with their mammalian hosts. Elucidating and understanding the molecular mechanisms by which microbiota interacts with its host and how this contributes to the homeostasis of the host is crucial. One of these molecular relationships is the so-called chemical crosstalk between microbiota and host metabolisms, including the poorly explored epigenetic regulation of host tissues by the metabolic activity of gut microbiota in response to changes in diet. DNA methylation and histone modifications are epigenetic marks partly regulated by enzymes such as methylases and acetylases, whose activity depend on host and microbiota metabolites that act as substrates and cofactors for these reactions. However, providing a complete mechanistic description of the regulatory interactions between both metabolisms and the impact on the expression of host genes through an epigenetic modulation, remains elusive. This article presents our perspective on how metabolomic, metagenomic, transcriptomic, and epigenomic data can be used to investigate the "microbiota-nutrient metabolism-epigenetics axis." We also discuss the implications and opportunities this knowledge may have for basic and applied science, such as the impact on the way we structure future research, understand, and prevent diseases like type 2 diabetes or obesity.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Molecular medicine Medicina veterinaria Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência da computação Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16648021
    Direcció de correo del autor: oscar.yanes@urv.cat joan.miro@estudiants.urv.cat
    Identificador del autor: 0000-0003-3695-7157 0000-0003-3179-0554
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fgene.2019.00638/full
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Frontiers In Genetics. 10 (JUL): 638-638
    Referencia de l'ítem segons les normes APA: Miro-Blanch, Joan; Yanes, Oscar (2019). Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism. Frontiers In Genetics, 10(JUL), 638-638. DOI: 10.3389/fgene.2019.00638
    DOI del artículo: 10.3389/fgene.2019.00638
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Genetics,Genetics & Heredity,Genetics (Clinical),Molecular Medicine
    Transplantation
    Transcription
    Posttranslational modifications
    Open chromatin
    Omics
    Microbiota
    Metabolomics
    Metabolism
    Impact
    Histones
    Epigenetics
    Donor feces
    Dna
    Diet-induced obesity
    Bacteria
    Acetylation
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Odontología
    Molecular medicine
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Genetics (clinical)
    Genetics & heredity
    Genetics
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
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