Articles producció científica> Medicina i Cirurgia

Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients

  • Datos identificativos

    Identificador: imarina:5873667
    Autores:
    Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, Blanco J, Vidal F, Pacheco YM, Rull A
    Resumen:
    The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could contribute to better understanding of the molecular mechanisms preceding a discordant response and HIV progression under suppressive combined antiretroviral therapy (cART). Integrated data from nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable the differentiation of HIV-infected subjects based on their immune recovery status after 96 weeks of suppressive cART. The metabolomic signature of ART-naïve HIV subjects with a subsequent late immune recovery is the expression of pro-inflammatory molecules and glutaminolysis, which is likely related to elevate T-cell turnover in these patients. The knowledge about how these metabolic pathways are interconnected and regulated provides new targets for future therapeutic interventions not only in HIV infection but also in other metabolic disorders such as human cancers where glutaminolysis is the alternative pathway for energy production in tumor cells to meet their requirement of rapid proliferation.© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
  • Otros:

    Autor según el artículo: Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, Blanco J, Vidal F, Pacheco YM, Rull A
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: HERRERO GIL, POL / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / Rodríguez Gallego, Esther / RULL AIXA, ANNA / SIRVENT CALVERA, JUAN JOSÉ / Veloso Esteban, Sergio / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria
    Palabras clave: Risk Poor immune recovery Pipecolic acid Nmr-based lipoprotein profile Ms-based metabolomics Mortality Macrophages Lymphocytes Low cd4 counts Inflammation Hiv Differentiation Cd4+ t-cell turnover Cart Antiretroviral therapy Activation
    Resumen: The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could contribute to better understanding of the molecular mechanisms preceding a discordant response and HIV progression under suppressive combined antiretroviral therapy (cART). Integrated data from nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable the differentiation of HIV-infected subjects based on their immune recovery status after 96 weeks of suppressive cART. The metabolomic signature of ART-naïve HIV subjects with a subsequent late immune recovery is the expression of pro-inflammatory molecules and glutaminolysis, which is likely related to elevate T-cell turnover in these patients. The knowledge about how these metabolic pathways are interconnected and regulated provides new targets for future therapeutic interventions not only in HIV infection but also in other metabolic disorders such as human cancers where glutaminolysis is the alternative pathway for energy production in tumor cells to meet their requirement of rapid proliferation.© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
    Áreas temáticas: Saúde coletiva Química Psicología Odontología Nutrição Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 01435221
    Direcció de correo del autor: sergio.veloso@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat esther.rodriguez@urv.cat francesc.vidal@urv.cat jesusmiguel.lopez@urv.cat
    Identificador del autor: 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-6692-6186 0000-0002-9141-2523
    Fecha de alta del registro: 2024-11-09
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://portlandpress.com/clinsci/article-abstract/133/8/997/218855/Glutaminolysis-and-lipoproteins-are-key-factors-in?redirectedFrom=fulltext
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Clinical Science. 133 (8): 997-1010
    Referencia de l'ítem segons les normes APA: Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, B (2019). Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients. Clinical Science, 133(8), 997-1010. DOI: 10.1042/CS20190111
    DOI del artículo: 10.1042/CS20190111
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Medicine, Research & Experimental
    Risk
    Poor immune recovery
    Pipecolic acid
    Nmr-based lipoprotein profile
    Ms-based metabolomics
    Mortality
    Macrophages
    Lymphocytes
    Low cd4 counts
    Inflammation
    Hiv
    Differentiation
    Cd4+ t-cell turnover
    Cart
    Antiretroviral therapy
    Activation
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
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