Autor según el artículo: Silvia Muñoz, Lucía Méndez, Gabriel Dasilva, Josep Lluís Torres, Sara Ramos-Romero, Marta Romeu, M. Rosa Nogués, Isabel Medina

Departamento: Ciències Mèdiques Bàsiques

e-ISSN: 1660-3397

Autor/es de la URV: Nogués Llort, Maria Rosa / Romeu Ferran, Marta

Palabras clave: Sprague-dawley rat Oxidative stress Marine omega-3 fatty acids Liver protein damage High-fat high-sucrose diet Fish oils Carbonylation sprague-dawley rat marine omega-3 fatty acids liver protein damage high-fat high-sucrose diet fish oils carbonylation

Resumen: The present study addressed the ability of long-chain ?-3 polyunsaturated fatty acids (?-3 PUFA), i.e., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), to ameliorate liver protein damage derived from oxidative stress and induced by consumption of high-caloric diets, typical of Westernized countries. The experimental design included an animal model of Sprague-Dawley rats fed high-fat high-sucrose (HFHS) diet supplemented with ?-3 EPA and DHA for a complete hepatic proteome analysis to map carbonylated proteins involved in specific metabolic pathways. Results showed that the intake of marine ?-3 PUFA through diet significantly decreased liver protein carbonylation caused by long-term HFHS consumption and increased antioxidant system. Fish oil modulated the carbonylation level of more than twenty liver proteins involved in critical metabolic pathways, including lipid metabolism (e.g., albumin), carbohydrate metabolism (e.g., pyruvate carboxylase), detoxification process (e.g., aldehyde dehydrogenase 2), urea cycle (e.g., carbamoyl-phosphate synthase), cytoskeleton dynamics (e.g., actin), or response to oxidative stress (e.g., catalase) among others, which might be under the control of diet marine ?-3 PUFA. In parallel, fish oil significantly changed the liver fatty acid profile given by the HFHS diet, resulting in a more anti-inflammatory phenotype. In conclusion, the present study highlights the significance of marine ?-3 PUFA intake for the health of rats fed a Westernized diet by describing several key metabolic pathways which are protected in liver.

Áreas temáticas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16603397

Direcció de correo del autor: mariarosa.nogues@urv.cat marta.romeu@urv.cat

Identificador del autor: 0000-0003-4626-5672 0000-0002-2131-1858

Fecha de alta del registro: 2023-02-18

Volumen de revista: 16

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1660-3397/16/10/353

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Marine Drugs. 16 (10): 353-360

Referencia de l'ítem segons les normes APA: Silvia Muñoz, Lucía Méndez, Gabriel Dasilva, Josep Lluís Torres, Sara Ramos-Romero, Marta Romeu, M. Rosa Nogués, Isabel Medina (2018). Targeting Hepatic Protein Carbonylation and Oxidative Stress Occurring on Diet-Induced Metabolic Diseases Through the Supplementation with Fish Oils. Marine Drugs, 16(10), 353-360. DOI: 10.3390/md16100353

DOI del artículo: 30261666

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications