Autor según el artículo: Guardia-Escote, Laia; Basaure, Pia; Biosca-Brull, Judit; Cabre, Maria; Blanco, Jordi; Perez-Fernandez, Cristian; Sanchez-Santed, Fernando; Domingo, Jose L; Teresa Colomina, Maria
Departamento: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia
Autor/es de la URV: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Palabras clave: Window Weaning Targeted replacement Short-chain fatty acids Mice, inbred c57bl Mice Metabolism Male Intestinal microbiota Insecticides Impact Health Gut microbiota Genotype Gastrointestinal microbiome Female Fatty acids, volatile Chlorpyrifos Butyrate Brain Body-weight Apolipoproteins e Apolipoprotein-e gene Apoe Animals Akkermansia-muciniphila Akkermansia muciniphila gut microbiota chlorpyrifos apoe akkermansia muciniphila
Resumen: © 2019 Elsevier Ltd The gut microbiota comprises a large number of microorganisms, whose composition can be modified by genetic and environmental factors. The host's genetic background, including the different isoforms of the apolipoprotein E (APOE) gene, can exert an influence over microbiota composition. Exposure to the widely-used pesticide chlorpyrifos (CPF), can lead to dysbiosis and alter the levels of metabolites produced by the microbiota, such as short-chain fatty acids (SCFAs). This study was aimed at assessing the contribution of the APOE genotype and early exposure to CPF on gut microbiota and SCFA in brain. For it, C57BL/6, apoE3-and apoE4-TR mice were orally exposed to CPF from postnatal day (PND) 10 to PND 15. Microbiota in the gut and SCFA in the brain were assessed at PND 15 after CPF exposure. Differences between genotypes at different taxonomic levels were found, A. muciniphila presented greater abundance in APOE4 genotype, but was reduced by CPF exposure. APOE and CPF influenced cerebral SCFAs, with APOE3 genotype showing the highest levels of acetic, propionic and butyric acids and CPF exposure inducing the highest levels of isovaleric and 4-methylvaleric acids. These results provide further knowledge about gut microbiota and cerebral SCFAs composition at early ages and their modulation by APOE and postnatal CPF exposure.
Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Direcció de correo del autor: maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat joseluis.domingo@urv.cat jordi.blanco@urv.cat mariateresa.colomina@urv.cat
Identificador del autor: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0001-8016-0984 0000-0002-5619-4874
Fecha de alta del registro: 2025-02-19
Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 135 (110872): 110872-
Referencia de l'ítem segons les normes APA: Guardia-Escote, Laia; Basaure, Pia; Biosca-Brull, Judit; Cabre, Maria; Blanco, Jordi; Perez-Fernandez, Cristian; Sanchez-Santed, Fernando; Domingo, Jo (2020). APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice. Food And Chemical Toxicology, 135(110872), 110872-. DOI: 10.1016/j.fct.2019.110872
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV