Autor según el artículo: Hereu, Merce; Ramos-Romero, Sara; Busquets, Cristina; Atienza, Lidia; Amezqueta, Susana; Miralles-Perez, Bernat; Rosa Nogues, Maria; Mendez, Lucia; Medina, Isabel; Lluis Torres, Josep;

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa

Palabras clave: Weight Supplementation Obesity Model Glucose Dysfunction Acids

Resumen: Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of D-fagomine and omega-3 PUFAs (EPA/DHA 1:1) on gut microbiota and related risk factors during early stages in the development of fat-induced pre-diabetes. Male Sprague Dawley (SD) rats were fed a standard diet, or a high-fat (HF) diet supplemented with D-fagomine, EPA/DHA 1:1, a combination of both, or neither, for 24 weeks. The variables measured were fasting glucose and glucose tolerance, plasma insulin, liver inflammation, fecal/cecal gut bacterial subgroups and short-chain fatty acids (SCFAs). The animals supplemented with D-fagomine alone and in combination with omega-3 PUFAs accumulated less fat than those in the non-supplemented HF group and those given only omega-3 PUFAs. The combined supplements attenuated the high-fat-induced incipient insulin resistance (IR), and liver inflammation, while increasing the cecal content, the Bacteroidetes:Firmicutes ratio and the populations of Bifidobacteriales. The functional effects of the combination of D-fagomine and EPA/DHA 1:1 against gut dysbiosis and the very early metabolic alterations induced by a high-fat diet are mainly those of D-fagomine complemented by the anti-inflammatory action of omega-3 PUFAs.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20452322

Direcció de correo del autor: bernat.miralles@urv.cat mariarosa.nogues@urv.cat bernat.miralles@urv.cat

Identificador del autor: 0000-0003-1294-7069 0000-0003-4626-5672 0000-0003-1294-7069

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.nature.com/articles/s41598-019-52678-5

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Scientific Reports. 9 (16628): 16628-

Referencia de l'ítem segons les normes APA: Hereu, Merce; Ramos-Romero, Sara; Busquets, Cristina; Atienza, Lidia; Amezqueta, Susana; Miralles-Perez, Bernat; Rosa Nogues, Maria; Mendez, Lucia; Me (2019). Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet. Scientific Reports, 9(16628), 16628-. DOI: 10.1038/s41598-019-52678-5

DOI del artículo: 10.1038/s41598-019-52678-5

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Tipo de publicación: Journal Publications