Autor según el artículo: Melia C; Soria V; Salvat-Pujol N; Cabezas Á; Nadal R; Urretavizcaya M; Gutiérrez-Zotes A; Monreal J; Crespo J; Alonso P; Vilella E; Palao D; Menchón J; Labad J
Departamento: Medicina i Cirurgia
Autor/es de la URV: Vilella Cuadrada, Elisabet
Palabras clave: Stress Sex differences Ocd Obsessive Cortisol
Resumen: BACKGROUND: Previous studies have shown associations between obsessive-compulsive disorder (OCD) and hypothalamic-pituitary-adrenal axis activity (HPA). We aimed to investigate the association between obsessive-compulsive (OC) symptoms and HPA axis functionality in a non-clinical sample and to explore whether there are sex differences in this relationship. METHODS: One hundred eighty-three healthy individuals without any psychiatric diagnosis (80 men, 103 women; mean age 41.3 ± 17.9 years) were recruited from the general population. The Obsessive-Compulsive Inventory Revised (OCI-R) was used to assess OC symptoms. State-trait anxiety, perceived stress, and stressful life events were also assessed. Saliva cortisol levels were determined at 6 time points (awakening, 30 and 60 min post-awakening, 10:00 a.m., 23:00 p.m. and 10:00 a.m. the following day of 0.25 mg dexamethasone intake [that occurred at 23:00 p.m.]). Three HPA axis measures were calculated: cortisol awakening response (CAR), cortisol diurnal slope, and cortisol suppression ratio after dexamethasone (DSTR). Multiple linear regression analyses were used to explore the association between OC symptoms and HPA axis measures while adjusting for covariates. Our main analyses were focused on OCI-R total score, but we also explored associations with specific OC symptom dimensions. RESULTS: No significant differences were observed between males and females in OC symptoms, anxiety measures, stress, or cortisol measures. In the multiple linear regression analyses between overall OC symptoms and HPA axis measures, a female sex by OC symptoms significant interaction (standardized beta = - 0.322; p = 0.023) for the CAR (but not cortisol diurnal slope nor DSTR) was found. Regarding specific symptom dimensions, two other sex interactions were found: a blunted CAR was associated with obsessing symptoms in women, whereas a more flattened diurnal cortisol slope was associated with ordering symptoms in men. CONCLUSIONS: There are sex differences in the association between OC symptoms and HPA axis measures in healthy individuals.
Áreas temáticas: Genetics & heredity Gender studies Endocrinology & metabolism Endocrinology Ciencias sociales Ciências biológicas ii
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20426410
Direcció de correo del autor: elisabet.vilella@urv.cat
Identificador del autor: 0000-0002-1887-5919
Fecha de alta del registro: 2023-02-22
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://bsd.biomedcentral.com/articles/10.1186/s13293-019-0273-3
Referencia al articulo segun fuente origial: Biology Of Sex Differences. 10 (1): 55-
Referencia de l'ítem segons les normes APA: Melia C; Soria V; Salvat-Pujol N; Cabezas Á; Nadal R; Urretavizcaya M; Gutiérrez-Zotes A; Monreal J; Crespo J; Alonso P; Vilella E; Palao D; Menchón J (2019). Sex-specific association between the cortisol awakening response and obsessive-compulsive symptoms in healthy individuals. Biology Of Sex Differences, 10(1), 55-. DOI: 10.1186/s13293-019-0273-3
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1186/s13293-019-0273-3
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications
Repositori URV