Articles producció científica> Medicina i Cirurgia

The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario

  • Datos identificativos

    Identificador: imarina:6013682
    Handle: http://hdl.handle.net/20.500.11797/imarina6013682
  • Autores:

    Girona, Josefa
    Rodriguez-Borjabad, Celia
    Ibarretxe, Daiana
    Vallve, Joan-Carles
    Ferre, Raimon
    Heras, Mercedes
    Rodriguez-Calvo, Ricardo
    Guaita-Esteruelas, Sandra
    Martinez-Micaelo, Neus
    Plana, Nuria
    Masana, Lluis
  • Otros:

    Autor según el artículo: Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Guaita-Esteruelas, Sandra; Martinez-Micaelo, Neus; Plana, Nuria; Masana, Lluis;
    Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    e-ISSN: 2077-0383
    Autor/es de la URV: FERRÉ VALLÈS, RAIMON / Girona Tell, Josefa / GUAITA ESTERUELAS, SANDRA / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Plana Gil, Núria / Vallvé Torrente, Joan Carles
    Palabras clave: Type 2 diabetes Resistance Obesity Obese Metabolic syndrome Mechanism Insulin Induction Homeostasis Grp78/bip Fenofibrate/niacin treatment Fenofibrate Er stress Endoplasmic reticulum stress Cholesterol Carotid intima-media thickness Cardiovascular risk Atherosclerosis Adipose-tissue obesity metabolic syndrome grp78/bip fenofibrate/niacin treatment endoplasmic reticulum stress carotid intima–media thickness cardiovascular risk atherosclerosis
    Resumen: Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and it is hyper-expressed in fat tissue of obese individuals. Objective: To investigate the role of the GRP78/BiP level as a metabolic and vascular disease biomarker in patients with type 2 diabetes (DM), obesity and metabolic syndrome (MS). Methods: Four hundred and five patients were recruited, of whom 52.5% were obese, 72.8% had DM, and 78.6% had MS. The intimae media thickness (cIMT) was assessed by ultrasonography. The plasma GRP78/BiP concentration was determined, and its association with metabolic and vascular parameters was assessed. Circulating GRP78/BiP was also prospectively measured in 30 DM patients before and after fenofibrate/niacin treatment and 30 healthy controls. Results: In the cross-sectional study, the GRP78/BiP level was significantly higher in the patients with obesity, DM, and MS. Age-, gender- and BMI-adjusted GRP78/BiP was directly associated with LDL-cholesterol, non-HDL-cholesterol, triglycerides, apoB, and cIMT. GRP78/BiP was positively associated to carotid plaque presence in the adjusted model, irrespective of obesity, DM and MS. In the prospective study, nicotinic acid treatment produced a significant reduction in the GRP78/BiP levels that was not observed with fenofibrate. Conclusions: GRP78/BiP plasma concentrations are increased in patients with both metabolic derangements and subclinical atherosclerosis. GRP78/BiP could be a useful marker of metabolic and cardiovascular risk.
    Áreas temáticas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20770383
    Direcció de correo del autor: daiana.ibarretxe@urv.cat josefa.girona@urv.cat jc.vallve@urv.cat nuria.plana@urv.cat luis.masana@urv.cat jc.vallve@urv.cat josefa.girona@urv.cat
    Identificador del autor: 0000-0002-6267-8779 0000-0002-4231-7618 0000-0002-0789-4954 0000-0002-6267-8779
    Fecha de alta del registro: 2023-06-09
    Volumen de revista: 8
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2077-0383/8/11/1793
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Clinical Medicine. 8 (11):
    Referencia de l'ítem segons les normes APA: Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Guaita-Es (2019). The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario. Journal Of Clinical Medicine, 8(11), -. DOI: 10.3390/jcm8111793
    DOI del artículo: 10.3390/jcm8111793
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Medicine, General & Internal
    Type 2 diabetes
    Resistance
    Obesity
    Obese
    Metabolic syndrome
    Mechanism
    Insulin
    Induction
    Homeostasis
    Grp78/bip
    Fenofibrate/niacin treatment
    Fenofibrate
    Er stress
    Endoplasmic reticulum stress
    Cholesterol
    Carotid intima-media thickness
    Cardiovascular risk
    Atherosclerosis
    Adipose-tissue
    obesity
    metabolic syndrome
    grp78/bip
    fenofibrate/niacin treatment
    endoplasmic reticulum stress
    carotid intima–media thickness
    cardiovascular risk
    atherosclerosis
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
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