Autor según el artículo: Soria-Florido MT, Castañer O, Lassale C, Estruch R, Salas-Salvadó J, Martínez-González MÁ, Corella D, Ros E, Arós F, Elosua R, Lapetra J, Fiol M, Alonso-Gómez A, Gómez-Gracia E, Serra-Majem L, Pintó X, Bulló M, Ruiz-Canela M, Sorlí JV, Hernáez Á, Fitó M

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge

Palabras clave: Sphingosine-1-phosphate Rupture Plaque High-density lipoproteins Heart-disease Hdl functions Hdl cholesterol Events Cholesterol efflux capacity Artery-disease Acute coronary syndrome

Resumen: Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that HDL atheroprotective role lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been comprehensively investigated. Methods: We conducted a case-control study nested within the PREDIMED (Prevención con Dieta Mediterránea) cohort, originally a randomized trial where participants followed a Mediterranean or low-fat diet. Incident acute coronary syndrome cases (N=167) were individually matched (1:2) to controls by sex, age, intervention group, body mass index, and follow-up time. We investigated its two individual manifestations (myocardial infarction, unstable angina) as secondary outcomes. We measured the following functional characteristics: HDL cholesterol concentration (in plasma); cholesterol efflux capacity; antioxidant ability measured by the HDL oxidative-inflammatory index; phospholipase A2 activity; and sphingosine-1-phosphate, apolipoproteins A-I and A-IV, serum amyloid A, and complement 3 protein (in apolipoprotein B-depleted plasma). We used conditional logistic regression models adjusted for HDL cholesterol levels and cardiovascular risk factors to estimate odds ratios (ORs) between one standard deviation increments in HDL functional characteristics and clinical outcomes. Results: Low values of cholesterol efflux capacity (OR1SD: 0.58, 95% CI: 0.40-0.83), and levels of sphingosine-1-phosphate (OR1SD: 0.70, 95% CI: 0.52-0.92), and apolipoprotein A-I (OR1SD: 0.58, 95% CI: 0.42-0.79) were associated with higher odds of acute coronary syndrome. Higher HDL oxidative inflammatory index values were marginally linked to acute coronary syndrome risk (OR1SD: 1.27, 95% CI: 0.99-1.63). Low values of cholesterol efflux capacity (OR1SD: 0.33, 95% CI: 0.18-0.61), sphingosine-1-phosphate (OR1SD: 0.60, 95% CI: 0.40-0.89) and apolipoprotein A-I (OR1SD: 0.59, 95% CI: 0.37-0.93) were particularly linked to myocardial infarction, whereas high HDL oxidative-inflammatory index values (OR1SD: 1.53, 95% CI: 1.01-2.33) and low apolipoprotein A-I levels (OR1SD: 0.52, 95% CI: 0.31-0.88) were associated with unstable angina. Conclusions: Low cholesterol efflux capacity values, pro-oxidant/pro-inflammatory HDL particles, and low HDL levels of sphingosine-1-phosphate and apolipoprotein A-I were associated with increased odds of acute coronary syndrome and its manifestations in high cardiovascular risk subjects. Clinical Trial Registration: URL: http://www.controlled-trials.com Unique identifier: ISRCTN35739639.

Áreas temáticas: Saúde coletiva Physiology (medical) Peripheral vascular disease Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar Hematology General medicine Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00097322

Direcció de correo del autor: jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de alta del registro: 2023-06-09

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041658

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Circulation. 141 (6): 444-453

Referencia de l'ítem segons les normes APA: Soria-Florido MT, Castañer O, Lassale C, Estruch R, Salas-Salvadó J, Martínez-González MÁ, Corella D, Ros E, Arós F, Elosua R, Lapetra J, Fiol M, Alon (2020). Dysfunctional HDLs are Associated with a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk: A Nested-Case Control Study. Circulation, 141(6), 444-453. DOI: 10.1161/circulationaha.119.041658

DOI del artículo: 10.1161/circulationaha.119.041658

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications