Autor según el artículo: Torres-Fuentes, C; Golubeva, AV; Zhdanov, AV; Wallace, S; Arboleya, S; Papkovsky, DB; El Aidy, S; Ross, P; Roy, BL; Stanton, C; Dinan, TG; Cryan, JF; Schellekens, H
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Torres Fuentes, Cristina
Palabras clave: Scfa Probiotics Motility Mechanisms Lactate Increase Hormone secretagogue receptor High constitutive activity Gut-brain axis Gut bacteria Ghsr-1a Expression Diet Cells Acute lung injury scfa lactate gut bacteria ghsr-1a
Resumen: The gastrointestinal microbiota is emerging as a unique and inexhaustible source for metabolites with potential to modulate G-protein coupled receptors (GPCRs). The ghrelin receptor [growth hormone secretagogue receptor (GHSR)-1a] is a GPCR expressed throughout both the gut and the brain and plays a crucial role in maintaining energy balance, metabolism, and the central modulation of food intake, motivation, reward, and mood. To date, few studies have investigated the potential of the gastrointestinal microbiota and its metabolites to modulate GPCR signaling. Here we investigate the ability of short-chain fatty acids (SCFAs), lactate, and different bacterial strains, including Bifidobacterium and Lactobacillus genera, to modulate GHSR-1a signaling. We identify, for what is to our knowledge the first time, a potent effect of microbiota-derived metabolites on GHSR-1a signaling with potential significant consequences for host metabolism and physiology. We show that SCFAs, lactate, and bacterial supernatants are able to attenuate ghrelin-mediated signaling through the GHSR-1a. We suggest a novel route of communication between the gut microbiota and the host via modulation of GHSR-1a receptor signaling. Together, this highlights the emerging therapeutic potential in the exploration of the microbiota metabolome in the specific targeting of key GPCRs, with pleiotropic actions that span both the CNS and periphery.
Áreas temáticas: Saúde coletiva Química Psicología Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Genetics General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Cell biology Biotecnología Biotechnology Biology Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 08926638
Direcció de correo del autor: cristina.torres@urv.cat
Identificador del autor: 0000-0002-2917-6910
Fecha de alta del registro: 2024-02-11
Versión del articulo depositado: info:eu-repo/semantics/submittedVersion
Enlace a la fuente original: https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.201901433Rhttps://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.201901433R
Referencia al articulo segun fuente origial: Faseb Journal. 33 (12): 13546-13559
Referencia de l'ítem segons les normes APA: Torres-Fuentes, C; Golubeva, AV; Zhdanov, AV; Wallace, S; Arboleya, S; Papkovsky, DB; El Aidy, S; Ross, P; Roy, BL; Stanton, C; Dinan, TG; Cryan, JF; (2019). Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling. Faseb Journal, 33(12), 13546-13559. DOI: 10.1096/fj.201901433R
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1096/fj.201901433R
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications