Autor según el artículo: Leal-Witt, Maria J.; Llobet, Marina; Samino, Sara; Castellano, Pol; Cuadras, Daniel; Jimenez-Chillaron, Josep C.; Yanes, Oscar; Ramon-Krauel, Marta; Lerin, Carles;

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica

Autor/es de la URV: SAMINO GENÉ, SARA / Yanes Torrado, Óscar

Palabras clave: Risk Phosphatidylcholine Overweight Metabolomics Metabolism Intestinal microbiota Impact Heart Childhood obesity Adulthood

Resumen: Objective: Early lifestyle interventions in children with obesity decrease risk of obesity and metabolic disorders during adulthood. This study aimed to identify metabolic signatures associated with lifestyle intervention in urine samples from prepubertal children with obesity. Methods: Thirty-four prepubertal children with obesity were studied before and after a 6-month lifestyle intervention program, and anthropometric, metabolic, and nutritional variables were collected. A nuclear magnetic resonance approach was applied to obtain the metabolomic profile from urine samples. Partial least squares-discriminant analysis (PLS-DA) was used to achieve group classification and variable importance on projection (VIP) for biomarker selection. Results: The intervention reduced caloric intake by 10% (P<0.05) and BMI standard deviation score by 0.47 SD (P<0.001). PLS-DA identified trimethylamine N-oxide (TMAO, VIP=2.21) as the metabolite with the highest discrimination properties between groups. Urine TMAO levels were reduced after the intervention (P<0.05). TMAO is a biomarker of cardiovascular disease risk and is a product of gut microbiota-dependent metabolism of certain dietary compounds, including choline. Notably, changes in TMAO levels after the intervention did not correlate to differences in choline intake but were inversely associated with fiber intake (P<0.05). Conclusions: These results indicate that lifestyle intervention decreases TMAO levels in children with obesity.

Áreas temáticas: Saúde coletiva Psicología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19307381

Direcció de correo del autor: oscar.yanes@urv.cat

Identificador del autor: 0000-0003-3695-7157

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22271

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Obesity. 26 (10): 1603-1610

Referencia de l'ítem segons les normes APA: Leal-Witt, Maria J.; Llobet, Marina; Samino, Sara; Castellano, Pol; Cuadras, Daniel; Jimenez-Chillaron, Josep C.; Yanes, Oscar; Ramon-Krauel, Marta; L (2018). Lifestyle Intervention Decreases Urine Trimethylamine N-Oxide Levels in Prepubertal Children with Obesity. Obesity, 26(10), 1603-1610. DOI: 10.1002/oby.22271

DOI del artículo: 10.1002/oby.22271

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications