Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Lifestyle Intervention Decreases Urine Trimethylamine N-Oxide Levels in Prepubertal Children with Obesity

  • Datos identificativos

    Identificador: imarina:6178125
    Autores:
    Leal-Witt, Maria JLlobet, MarinaSamino, SaraCastellano, PolCuadras, DanielJimenez-Chillaron, Josep CYanes, OscarRamon-Krauel, MartaLerin, Carles
    Resumen:
    Objective: Early lifestyle interventions in children with obesity decrease risk of obesity and metabolic disorders during adulthood. This study aimed to identify metabolic signatures associated with lifestyle intervention in urine samples from prepubertal children with obesity. Methods: Thirty-four prepubertal children with obesity were studied before and after a 6-month lifestyle intervention program, and anthropometric, metabolic, and nutritional variables were collected. A nuclear magnetic resonance approach was applied to obtain the metabolomic profile from urine samples. Partial least squares-discriminant analysis (PLS-DA) was used to achieve group classification and variable importance on projection (VIP) for biomarker selection. Results: The intervention reduced caloric intake by 10% (P<0.05) and BMI standard deviation score by 0.47 SD (P<0.001). PLS-DA identified trimethylamine N-oxide (TMAO, VIP=2.21) as the metabolite with the highest discrimination properties between groups. Urine TMAO levels were reduced after the intervention (P<0.05). TMAO is a biomarker of cardiovascular disease risk and is a product of gut microbiota-dependent metabolism of certain dietary compounds, including choline. Notably, changes in TMAO levels after the intervention did not correlate to differences in choline intake but were inversely associated with fiber intake (P<0.05). Conclusions: These results indicate that lifestyle intervention decreases TMAO levels in children with obesity.
  • Otros:

    Autor según el artículo: Leal-Witt, Maria J; Llobet, Marina; Samino, Sara; Castellano, Pol; Cuadras, Daniel; Jimenez-Chillaron, Josep C; Yanes, Oscar; Ramon-Krauel, Marta; Lerin, Carles
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: SAMINO GENÉ, SARA / Yanes Torrado, Óscar
    Palabras clave: Risk Phosphatidylcholine Overweight Metabolomics Metabolism Intestinal microbiota Impact Heart Childhood obesity Adulthood
    Resumen: Objective: Early lifestyle interventions in children with obesity decrease risk of obesity and metabolic disorders during adulthood. This study aimed to identify metabolic signatures associated with lifestyle intervention in urine samples from prepubertal children with obesity. Methods: Thirty-four prepubertal children with obesity were studied before and after a 6-month lifestyle intervention program, and anthropometric, metabolic, and nutritional variables were collected. A nuclear magnetic resonance approach was applied to obtain the metabolomic profile from urine samples. Partial least squares-discriminant analysis (PLS-DA) was used to achieve group classification and variable importance on projection (VIP) for biomarker selection. Results: The intervention reduced caloric intake by 10% (P<0.05) and BMI standard deviation score by 0.47 SD (P<0.001). PLS-DA identified trimethylamine N-oxide (TMAO, VIP=2.21) as the metabolite with the highest discrimination properties between groups. Urine TMAO levels were reduced after the intervention (P<0.05). TMAO is a biomarker of cardiovascular disease risk and is a product of gut microbiota-dependent metabolism of certain dietary compounds, including choline. Notably, changes in TMAO levels after the intervention did not correlate to differences in choline intake but were inversely associated with fiber intake (P<0.05). Conclusions: These results indicate that lifestyle intervention decreases TMAO levels in children with obesity.
    Áreas temáticas: Saúde coletiva Psicología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 19307381
    Direcció de correo del autor: oscar.yanes@urv.cat
    Identificador del autor: 0000-0003-3695-7157
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22271
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Obesity. 26 (10): 1603-1610
    Referencia de l'ítem segons les normes APA: Leal-Witt, Maria J; Llobet, Marina; Samino, Sara; Castellano, Pol; Cuadras, Daniel; Jimenez-Chillaron, Josep C; Yanes, Oscar; Ramon-Krauel, Marta; Ler (2018). Lifestyle Intervention Decreases Urine Trimethylamine N-Oxide Levels in Prepubertal Children with Obesity. Obesity, 26(10), 1603-1610. DOI: 10.1002/oby.22271
    DOI del artículo: 10.1002/oby.22271
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2018
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Endocrinology,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Risk
    Phosphatidylcholine
    Overweight
    Metabolomics
    Metabolism
    Intestinal microbiota
    Impact
    Heart
    Childhood obesity
    Adulthood
    Saúde coletiva
    Psicología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Endocrinology
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
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